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Articles by Keisuke Ejima
Optimizing mouse models for mRNA vaccines: addressing dose translation challenges
Abstract The development of mRNA vaccines has significantly advanced global health during the COVID-19 pandemic. However, translating effective vaccine doses from preclinical animal models to human clinical use remains poorly understood. In this study, we evaluated antibody responses and repertoire diversity across different BNT162b2 mRNA vaccine doses in mice, while comparing the results with human data through mathematical modeling.
"Conditioning on Parental Mating Types Can Reduce Necessary Assumptions" by Keisuke Ejima, Nianjun Liu et al.
Keywords Mendelian randomization, genetic epidemiology, causal inference, study design, linkage disequilibrium Abstract Mendelian randomization (MR) has become a common tool used in epidemiological studies. However, when confounding variables are correlated with the instrumental variable (in this case, a genetic/variant/marker), the estimation can remain biased even with MR.
Age- and vaccination status-dependent isolation guidelines based on simulation of SARS-CoV-2 Delta cases in Singapore - Communications Medicine
Abstract In the absence of effective pharmaceutical interventions early in an infectious disease outbreak, non-pharmaceutical measures, especially isolating infected individuals, critically limit its impact. The ongoing COVID-19 pandemic has sparked debates on optimal isolation guidelines. This study proposes a variable isolation period approach (variable-period approach), tailoring isolation durations for distinct population groups with varied viral load dynamics.
Designing isolation guidelines for COVID-19 patients with rapid antigen tests - Nature Communications
Abstract Appropriate isolation guidelines for COVID-19 patients are warranted. Currently, isolating for fixed time is adopted in most countries. However, given the variability in viral dynamics between patients, some patients may no longer be infectious by the end of isolation, whereas others may still be infectious.
Detection of significant antiviral drug effects on COVID-19 with reasonable sample sizes in randomized controlled trials: A modeling study
Loading metrics Open Access Peer-reviewed Research Article Shoya Iwanami , Keisuke Ejima , Kwang Su Kim, Koji Noshita, Yasuhisa Fujita, Taiga Miyazaki, Shigeru Kohno, Yoshitsugu Miyazaki, Shimpei Morimoto, Shinji Nakaoka, Yoshiki Koizumi, Yusuke Asai, Kazuyuki Aihara, Koichi Watashi, Robin N. Thompson, Kenji Shibuya, Katsuhito Fujiu, Alan S. Perelson , Shingo Iwami , [ ...
A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2
Loading metrics Open Access Peer-reviewed Research Article Kwang Su Kim , Keisuke Ejima , Shoya Iwanami, Yasuhisa Fujita, Hirofumi Ohashi, Yoshiki Koizumi, Yusuke Asai, Shinji Nakaoka, Koichi Watashi, Kazuyuki Aihara, Robin N. Thompson, Ruian Ke, Alan S.
Associations of breastfeeding or formula feeding with infant anthropometry and body composition at 6 months
Abstract The objective of this study was to investigate the associations of mode of feeding with infant anthropometric and body composition variables at 6 months of age. We studied 259 infants whose exclusive mode of feeding (breast or formula) to 1 month was confirmed.
Subconcussive head impact exposure between drill intensities in U.S. high school football
Loading metrics Open Access Peer-reviewed Research Article Kyle Kercher, Jesse A. Steinfeldt, Jonathan T. Macy, Keisuke Ejima, Keisuke Kawata Kyle Kercher, Jesse A. Steinfeldt, Jonathan T. Macy, Keisuke Ejima, Keisuke Kawata Published: August 14, 2020 https://doi.org/10.1371/journal.pone.0237800 Figures Abstract USA Football established five levels-of-contact to guide the intensity of high school football practices.
Toward Fulfilling the Aspirational Goal of Science as Self‐Correcting: A Call for Editorial Courage and Diligence for Error Correction
EDITORIAL David B.
Number of infection events per cell during HIV-1 cell-free infection
HEK293T cells were maintained in Dulbecco modified Eagle’s medium (DMEM) supplemented with 10% heat-inactivated foetal calf serum (FCS) and antibiotics (100 IU/ml penicillin and 100??g/ml streptomycin). MT4R5 cells19 were grown in RPMI-1640 medium supplemented with 10% heat-inactivated FCS, 100?IU/ml of penicillin, 100?µg/ml of streptomycin, and 0.25??g/ml of amphotericin B. All cultures were maintained at 37?°C in a humidified atmosphere with 5% CO .
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