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Barnaby Young

As seen in: Nature, The Telegraph, Wiley Online Library, Yahoo Canada, Educational Studies, Gut Journal, MDPI, Taylor & Francis Online, JAMA: Journal of the American Medical Association, CNA (Channel NewsAsia) and
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Articles

Programmable antibody-based chimeric entry receptors for sarbecoviruses

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By Yidan Wang, Wilaiporn Saikruang, Kei Sato, Feng Zhu, Han Wang, Barnaby Young, Haifeng Ye, Lin-Fa Wang, Zi Wei Chia
| Nature Verified
Abstract Despite frequent spillover of sarbecoviruses, most SARS-related viruses discovered in animals fail to engage human ACE2 (hACE2), limiting mechanistic insight and risk assessment. Here we developed antibody-based chimeric entry receptors (ABCERs) that reprogram antibody-antigen recognition into a synthetic, cell-anchored receptor interface.
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Optimizing mouse models for mRNA vaccines: addressing dose translation challenges

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By Zi Wei Chang, Yong Tan, Yun Shan Goh, Yuqian Wang, Chiew Yee Loh, Yuling Huang, Bei Wang, Cheng-I Wang, David Lye, Barnaby Young, Matthew Zirui Tay, Lisa Ng, Keisuke Ejima, Laurent Renia, Yiyu Liao, Syed Ridwan Kabir, Pei Xiang Hor
| Nature Verified
Abstract The development of mRNA vaccines has significantly advanced global health during the COVID-19 pandemic. However, translating effective vaccine doses from preclinical animal models to human clinical use remains poorly understood. In this study, we evaluated antibody responses and repertoire diversity across different BNT162b2 mRNA vaccine doses in mice, while comparing the results with human data through mathematical modeling.
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Early administration of neutralising monoclonal antibodies and post-acute sequelae of COVID-19

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By Barnaby Young
| International Journal of Infectious Disease Verified
Discussion The early administration of neutralising mAbs had been a part of the acute management of COVID-19, in individuals who were unvaccinated or who are immunocompromised, which had been effective in reducing the risk of progression to oxygen requirement in the short term. Longer-term implications on PASC remained unclear. In our cohort, we found that early treatment with mAbs did not significant alter the PASC overall.
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