Keisuke Matsubara

1 Introduction Skin plays protective roles in the human body by acting as a physical and immunological barrier against chemical hazards and pathogens threatening homeostasis. To defend against external threats, cutaneous immune responses primarily occur in the epidermis and papillary dermis in superficial skin sites, which constitute the epithelial–immune microenvironment (EIME) (1).

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eLife assessment This study presents a valuable inventory of immune signatures that are correlated with cancer treatment-related pneumonitis. The data were collected and analyzed using validated methodology and can be used as a starting point for further prospective studies. The authors have provided an scRNA-seq analysis with an HD baseline using publicly available dataset and the evidence for their claims is convincing.