Keith Richardson on Muck Rack

Keith Richardson

United Kingdom
As seen in: Nature, Wiley Online Library, ACS Publications, JAMA (The Journal of the American Medical Association), Cell Reports, Lexology, KLMR-AM (Lamar, CO)
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Articles

Structural heterogeneity and substrate engagement mechanism of the bacterial proteasome activator Bpa - Nature Communications

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By Bradley Davis, Enrico Rennella, Anisha Haris, Jakub Ujma, David Bruton, Keith Richardson, Kevin Giles Verified, Lewis E. Kay, Siavash Vahidi
| Nature Verified
Abstract Bacterial proteasomal activator (Bpa) is a regulatory particle of the Mycobacterium tuberculosis proteasome that facilitates the recruitment of substrates and their subsequent degradation by the 20S core particle. Substrate-bound structures of Bpa are unavailable, leaving its recruitment mechanism incompletely understood.
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Pretreatment Neutrophil‐to‐Lymphocyte Ratio (NLR) Predicts Treatment Toxicity and Intolerance in Operable Head and Neck Cancer: An Ambispective Cohort Study

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By Raisa Chowdhury, Karim Botros, Keith Richardson, Alex M. Mlynarek
| Wiley Online Library Verified
1 Introduction The incidence of head and neck cancers (HNC) continues to rise worldwide, with the most recent global statistics reporting 946 456 new cases and 482 001 deaths in 2022 [1]. Treatment is multimodal, consisting of surgery, radiation, and chemotherapy [2, 3]. Management of post-operative complications remains critical, as complications can delay or prevent adjuvant therapies, with direct implications on survival outcomes.
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Sarcopenia Trajectories Predict Survival in Operable Head and Neck Cancer

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By Marco A. Mascarella, Alex Marcin Mlynarek, Keith Richardson, Karen M. Kost
| Wiley Online Library Verified
1 Introduction Head and neck squamous cell cancer (HNSCC) represents a unique set of tumors that impact critical functions of the upper aerodigestive tract. These malignancies often affect mechanisms of swallowing and breathing, which ultimately contribute to malnutrition and cachexia [1-4]. Compounded by the radical nature of therapies, such patients are often afflicted with multiple treatment toxicities as a means to achieve disease control.
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