Kendale Wirtjes on Muck Rack

Kendale Wirtjes

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Articles

Space-associated stem cell hallmarks of aging and resilience in astronauts

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By Jessica Pham, Shuvro P Nandi, Larisa Balaian, Claire Engstrom, Patrick S. Chang, Jenna Sneifer, Antonio Ruiz, Daisy Chilin-Fuentes, Elsa Molina, Pinar Mesci, Sheldon R. Morris, Thomas C. Whisenant, Ludmil B. Alexandrov, Catriona Jamieson, Karla Mack, Emma Klacking, Neha Katragadda, Kendale Wirtjes, Jana Stoudemire
| Cell Stem Cell Verified
Keywords spaceflight astronauts hematopoietic stem and progenitor cells ADAR1 APOBEC3C retrotransposons telomere mitochondria clonal mutations resilience Introduction Lifelong blood cell production and effective immune responses are predicated on the maintenance of healthy hematopoietic stem cells (HSCs) that can reside dormant in protective niches, mobilize following a “fight or flight” response, self-renew (regenerate), and differentiate into all blood cell types.1,2,3,4,5,6,7,8 Hallmarks...
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