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Kendra Musmaker

As seen in: Nature, MDPI
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Articles

Highly mutagenic copying of telomeric circles promotes ALT establishment

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By Meng-Chia Tsai, Jacob Wells, Kendra Musmaker, Ryan Pellow, Andrey Malkov, Josep M. Comeron, Anna Malkova, Kelley A. Renninger
| Nature Verified
Abstract Alternative lengthening of telomeres (ALT) is a recombination-based pathway enabling cancer cells to maintain telomeres. ALT establishment remains poorly understood due to difficulties identifying its molecular steps. Here, using Oxford Nanopore sequencing and computational modeling, we track the evolution of individual chromosome end structures during ALT establishment in yeast and delineate three molecular milestones.
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Alternative Lengthening of Telomeres in Yeast: Old Questions and New Approaches

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By Jacob Wells, Josep M. Comeron, Kendra Musmaker, Meng-Chia Tsai
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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