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Josep M. Comeron on Muck Rack

Josep M. Comeron

Iowa City
As seen in: Nature, PLOS, MDPI, BioRxiv, Cell Press
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Articles

Highly mutagenic copying of telomeric circles promotes ALT establishment

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By Meng-Chia Tsai, Jacob Wells, Kendra Musmaker, Ryan Pellow, Andrey Malkov, Josep M. Comeron, Anna Malkova, Kelley A. Renninger
| Nature Verified
Abstract Alternative lengthening of telomeres (ALT) is a recombination-based pathway enabling cancer cells to maintain telomeres. ALT establishment remains poorly understood due to difficulties identifying its molecular steps. Here, using Oxford Nanopore sequencing and computational modeling, we track the evolution of individual chromosome end structures during ALT establishment in yeast and delineate three molecular milestones.
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A wavelet-based approach generates quantitative, scale-free and hierarchical descriptions of 3D genome structures and new biological insights

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By Ryan Pellow, Josep M. Comeron
| PLOS
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Pellow R, Comeron JM (2026) A wavelet-based approach generates quantitative, scale-free and hierarchical descriptions of 3D genome structures and new biological insights. PLoS Comput Biol 22(1): e1013887.
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A wavelet-based approach generates quantitative, scale-free and hierarchical descriptions of 3D genome structures and new biological insights

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By Josep M. Comeron, Ryan Pellow
| BioRxiv
Abstract Eukaryotes fold their genomes within nuclei in three-dimensional space, with coordinated multiscale structures including loops, topologically associating domains (TADs), and higher-order chromosome territories. This 3D organization plays essential roles in gene regulation and development, responses to physiological stress, and disease. However, current methodologies to infer these 3D structures from genomic data have limitations.
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