Keng Yoon Yeong

1 Introduction Recent advancements in drug innovation and medicinal chemistry have underscored the significance of the benzimidazole scaffold.[1-3] This planar, heterocyclic moiety acts as an interesting building block for the synthesis of numerous biologically active compounds that have been shown to possess a wide spectrum of unique properties.[4-7] Diverse synthetic strategies have been developed wherein the benzimidazole scaffold can be modified to produce a variety of functionalized...

INTRODUCTION Antimicrobial multidrug resistance (AMR) is a pressing global health issue exacerbated by the overuse and misuse of antibiotics across various sectors, including medicine, agriculture, livestock, and aquaculture.1 Although the development of new antibiotics is crucial for combating AMR, it has become increasingly difficult to bring new antibiotics to market, mainly due to the high costs involved and the exit of major pharmaceutical companies from this area.