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Kengna Fan

As seen in: Frontiers in Immunology
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Articles

Bile acid metabolomics reveals distinct immunometabolic niches and enables accurate diagnosis of AQP4-IgG–seronegative NMOSD

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By zixin Chen, Yuchen Ye, Yanping Lan, Renquan Jiang, Xin Yang, Xinyao Yang, Xinrong Lu, Qunfang Huang, Can Liu, Qishui Ou, Zhen Xun, Kengna Fan, Xiaxia Qiu, Yujue He
| Frontiers in Immunology
Abstract Background and Objective: Differentiating neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS) is clinically difficult, especially when patients are seronegative for anti–aquaporin-4 immunoglobulin G (AQP4-IgG). Bile acids (BAs) function as important immunoregulatory metabolites, yet their metabolic signatures have not been profiled across NMOSD subtypes or compared with MS. We therefore profiled BA metabolism in NMOSD and MS to determine diagnostic utility.
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