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Keun Young Min

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Articles

Peritoneal mast cell-derived IL-10 promotes peritoneal-colon tolerance by reprogramming macrophages to ameliorate colitis

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By Min Choi, Min Geun Jo, Jueng Soo You, Hyuk Soon Kim, Sunsook Hwang, Wahn Soo Choi, Keun Young Min
| Nature Verified
Abstract Maintaining peripheral tolerance is critical for mucosal homeostasis. The peritoneal cavity (PerC), a gut-adjacent immune niche exposed to microbial products, contains mast cells (MCs) whose regulatory role in colitis is unclear. Here we show that IL-10 derived from MCs restrains colitis by programming anti-inflammatory macrophages along the PerC-colon axis.
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