Sunsook Hwang

1 Introduction Obesity, a physical condition defined as abnormal or excessive accumulation of fat, is increasing worldwide.[1] Epidemiological studies reveal strong links between obesity and at least 13 types of cancer, including colorectal, liver, breast and prostate cancers.[2] Moreover, accruing evidence suggests that obesity is closely associated with inferior clinical outcomes of cancer therapy.[3] Indeed, many cancer patients with obesity suffer from chemotherapy failure, cancer...

Abstract The immune system has been extensively studied in traditional immune hubs like the spleen and lymph nodes. However, recent advances in immunology highlight unique immune cell characteristics across anatomical compartments. In this study, we challenged conventional thinking by uncovering distinct immune cell populations within the brain parenchyma, separate from those in the blood, meninges, and choroid plexus, with unique transcriptional profiles.