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Novel Therapeutics in the Search for Disease Modification in Parkinson’s Disease - a Rapid Review of the Literature
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Multi-omics characterization of highly enriched human plasma extracellular vesicles.
Abstract Extracellular vesicles (EVs) in blood plasma offer a valuable reservoir of intracellular cellular cargo, making them a promising source of liquid based biomarkers. The molecular cargo of small EVs (sEVs) is of particular interest because some EV subtypes encapsulate cargo from organelles including mitochondria, endosomes, and the autophagy pathways, which are implicated in multiple diseases.
Exploring the significance of lipids in Alzheimer's disease and the potential of extracellular vesicles
AD Alzheimer's disease APP amyloid precursor protein Aβ amyloid-β BDEV brain-derived extracellular vesicles BMP bis(monoacylglycerol)phosphate CDR clinical dementia rating CNS central nervous system CSF cerebrospinal fluid DG diglyceride DHA docosahexaenoic acid EAL pathways endosomal, autophagy, and lysosomal pathways FFA free fatty acid GL glycerolipids GP glycerophospholipids HDL high-density lipoproteins LBD Lewy body disorders LBPA lysobisphosphatidic acid LDL/VLDL low-density...
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