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Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish
Highlights • Vitamin D activates cardiomyocyte proliferation in several contexts in zebrafish • Vitamin D controls growth rate and cycling in a wide range of adult cells • Tissue-specific modulation of vitamin D activity controls cardiac size • ErbB2 inhibition blunts vitamin D-induced cell proliferation Summary Attaining proper organ size during development and regeneration hinges on the activity of mitogenic factors.
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