Khalad Karram on Muck Rack

Khalad Karram

As seen in: Cell Press
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Articles

Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology

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By Khalad Karram, Giovanni Di Liberto, Alma Nazlie Mohebiany, Nishada Shakunty Ramphal
| Cell Press Verified
Highlights • A20-deficient microglia acquire an inflammatory signature seen in viral infections • CD8+ T cells infiltrate the CNS when microglia lack A20 • Infiltrating CD8+ T cells are responsible for phenotypic changes in microglia and neurons • Cortical neurons are hyperactive and have an increased number of synaptic terminals Summary Tumor-necrosis-factor-alpha-induced protein 3 (TNFAIP3), or A20, is a ubiquitin-modifying protein and negative regulator of canonical nuclear factor κB...
Open in Who Shared Issue with article?
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By Florian Wanke, Juan Zhang, Sonja Moos, Andrew L. Croxford, André P. Heinen, Stephanie Gräf, Bettina Kalt, Denise Tischner, Isabelle Christen, Julia Bruttger, Nir Yogev, Yilang Tang, Morad Zayoud, Khalad Karram, Sonja Reißig, Sonja M. Lacher
| secure.jbs.elsevierhealth.com
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