Khayam Javed on Muck Rack

Khayam Javed

As seen in: PNAS
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Articles

DNA-induced spatial entrapment of general transcription machinery can stabilize gene expression in a nondividing cell

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By Khayam Javed, Gaurav Agarwal, Nicola Lawrence, Jerome Jullien
| PNAS Verified
Significance How differentiated cells such as muscle or nerve maintain their gene expression for prolonged times is currently elusive. Here, using Xenopus oocyte, we have shown that the stability of gene expression in nondividing cells may arise due to the local entrapment of transcriptional machinery to specific gene transcription start sites. We found that within the same nucleus active versus inactive versions of the same gene are spatially segregated through liquid–liquid phase separation.
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Long-term association of a transcription factor with its chromatin binding site can stabilize gene expression and cell fate commitment

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By of Cambridge, Munender Vodnala, J. B. Gurdon, Khayam Javed
| PNAS Verified
Long-term association of a transcription factor with its chromatin binding site can stabilize gene expression and cell fate commitment J. B. Gurdon, Khayam Javed, Munender Vodnala, Nigel Garrett Proceedings of the National Academy of Sciences Jun 2020, 202000467; DOI: 10.1073/pnas.2000467117
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