Khoa Ngo

Inactivated-state clusters As inactivation is known to affect the SF, we grouped the models by focusing exclusively on similarity of the SF (S624–G628) conformations. We ranked the clusters according to the average pLDDT of these specific residues. This method led to the identification of four main clusters and one outlier.

Abstract To design safe, selective, and effective new therapies, there must be a deep understanding of the structure and function of the drug target. One of the most difficult problems to solve has been resolution of discrete conformational states of transmembrane ion channel proteins. An example is KV11.1 (hERG), comprising the primary cardiac repolarizing current, IKr. hERG is a notorious drug anti-target against which all promising drugs are screened to determine potential for arrhythmia.

Índices biométricos oculares en vietnamitas de 46 a 65 años de edad Autores: Hien Thi Thu Nguyen, Khoa Xuan Ngo, Luan Thanh Nguyen, Luong Van Hoang Localización: Revista Cubana de Medicina Militar, ISSN-e 1561-3046, ISSN 0138-6557, Vol. 50, Nº.