Khoi Huynh

Abstract Large-scale gradients of functional connectivity between brain areas organize the human neocortex, linking brain topography to the texture of cognition1,2. In adults, three dominant axes—sensory–association, visual–somatosensory and modulation–representation—run, respectively, from primary sensory to transmodal association areas, from visual to body-centred systems and from control and attention networks to default mode and sensory areas1,2,3,4.

Abstract Diffusion tractography, a cornerstone of white matter mapping, relies on point-to-point streamline propagation, a process often limited by the signal-to-noise ratio and spatioangular resolution of diffusion MRI (dMRI). Here, we present Anatomy-to-Tract Mapping (ATM), a framework that generates bundle-specific streamlines directly from T1-weighted MRI without requiring orientation field estimation, voxelwise segmentation, or streamline propagation.

Abstract Despite the cerebellum’s crucial role in brain function, its early development, particularly in relation to the cerebrum, remains poorly understood. Here, we examine cerebellocortical connectivity using over 1000 high-quality resting-state functional MRI scans from children between birth and five years of age. By mapping cerebellar topography with fine temporal granularity, we unveil the hierarchical organization of cerebellocortical functional connectivity from infancy.