Pew-Thian Yap

Abstract Deciphering how the human brain matures and reorganizes across the lifespan remains a central challenge in developmental neuroscience. Understanding the complex developmental processes is essential for elucidating the biological bases of cognition and behavior, as well as the mechanisms underlying aging and neurodegenerative diseases. Neuroimaging has enabled the mapping of nonlinear, age-related changes in brain morphology, microstructure, and connectivity from gestation to senescence.

Abstract Large-scale gradients of functional connectivity between brain areas organize the human neocortex, linking brain topography to the texture of cognition1,2. In adults, three dominant axes—sensory–association, visual–somatosensory and modulation–representation—run, respectively, from primary sensory to transmodal association areas, from visual to body-centred systems and from control and attention networks to default mode and sensory areas1,2,3,4.

Supporting Information Filename Description nbm5302-sup-0001-FigureS1.tiffTIFF image, 3.3 MB Figure S1 T1 and T2 maps obtained using dictionary matching and all ~2300 time points from the SMS-MRF acquisitions. Only one representative slice is shown for each SMS-MRF scan and the results obtained using single-slice 2D MRF (~2300 time points) from the same slice position are also plotted for comparison. (A) MB factor of 3; (B) MB factor of 4.