Ki Woo Kim

Abstract Zinc oxide nanoparticles (ZnO-NPs) have attracted considerable interest for biomedical applications due to their favorable physicochemical and biological properties; however, their biological effects are highly concentration-dependent, and optimal conditions for osteogenic effects remain unclear. In this study, we aimed to systematically evaluate the concentration-dependent effects of ZnO-NP extracts on osteogenic responses in pre-osteoblastic cells.

Abstract The aberrant Wnt/β-catenin signaling is tightly associated with developmental disorders and tumorigenesis. However, spatial regulation of cytoplasmic β-catenin with regard to its nuclear accumulation and signaling activation remains poorly understood. Herein, we show that mitochondrial adenylate kinase 3 (AK3), which is involved in the TCA cycle, regulates nuclear β-catenin localization and its activation.

Abstract The microbiota-derived short-chain fatty acid (SCFA), butyrate influences host metabolism beyond the gut, including central regulation of appetite and energy homeostasis. However, mechanistic insights into central butyrate metabolic actions are undetermined. Here, we demonstrated that primary cilia of agouti-related peptide (AgRP) neurons in the hypothalamic arcuate nucleus are essential for butyrate’s anorexigenic effects and glucose homeostasis.