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Sang Hee Lyoo on Muck Rack

Sang Hee Lyoo

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Articles

Primary cilia in the hypothalamic AgRP neurons mediate metabolic effects of butyrate

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By Dong Yang, Khanh Van Doan, Aran Lee, Yun-Hee Choi, Ki Woo Kim, Santosh Rijal, Sang Hee Lyoo, Dong Min Shin
| Nature Verified
Abstract The microbiota-derived short-chain fatty acid (SCFA), butyrate influences host metabolism beyond the gut, including central regulation of appetite and energy homeostasis. However, mechanistic insights into central butyrate metabolic actions are undetermined. Here, we demonstrated that primary cilia of agouti-related peptide (AgRP) neurons in the hypothalamic arcuate nucleus are essential for butyrate’s anorexigenic effects and glucose homeostasis.
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