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Kíra A. Häfner on Muck Rack

Kíra A. Häfner

As seen in: Nature
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Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity

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By Noé Seija, Tim M Gemeinhardt, Diego Alvarez, Melanie Provencher, Poorani Ganesh Subramani, Christian Poitras, Eva-Maria Piskor, Tarik Moroy, Nicholas Vonniessen, Bruce Mazer, Nicole J. Francis, François Robert, Javier M. Di Noia, Sophia Gannon, Kíra A. Häfner, Jana Ridani, Marcelo A. Navarrette
| Nature Verified
Abstract Activation-induced deaminase (AID) drives antibody diversification through class-switch recombination and somatic hypermutation of the immunoglobulin (Ig) genes, but its off-target mutagenic activity contributes to B cell lymphoma1,2,3,4,5. How AID selectively mutates Ig loci and a restricted set of other genes remains unknown. Transcription is required for AID activity, but most transcribed genes are not mutated1,5,6,7, and AID occupies more loci than it mutates7,8,9.
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