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Kirston Barton

As seen in: BioRxiv, Cell Press
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Articles

Repeat-rich regions cause false positive detection of NUMTs - a case study in amphibians using an improved cane toad reference genome

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By Kelton Cheung, Jillian Hammond, Kirston Barton, Lee Ann Rollins
| BioRxiv
Abstract Mitochondrial DNA (mtDNA) has been widely used in genetics research for decades. Contamination from nuclear DNA of mitochondrial origin (NUMT) can confound studies of phylogenetic relationships and mtDNA heteroplasmy. Homology searches with mtDNA are widely used to detect NUMTs in the nuclear genome.
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Adaptation of Oxford Nanopore technology for hepatitis C whole genome sequencing and identification of within-host viral variants

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By Chaturaka Rodrigo, Preston Leung, Kirston Barton, Nasir Riaz
| Biomed Central (BMC)
Research article Open Access Published: 02 March 2021 Nasir Riaz1,2, Preston Leung1, Kirston Barton3, Martin A. Smith3, Shaun Carswell3, Rowena Bull1,4, Andrew R. Lloyd1 & Chaturaka Rodrigo ORCID: orcid.org/0000-0003-2189-91771,4 BMC Genomics volume 22, Article number: 148 (2021) Cite this article 580 Accesses 13 Altmetric Metrics details Abstract Background Hepatitis C (HCV) and many other RNA viruses exist as rapidly mutating quasi-species populations in a single infected host.
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Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants

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By John-Sebastian Eden, Bonnie Hiener, Bethany A. Horsburgh, Kirston Barton
| Cell Press Verified
Latent HIV-1 Reservoirs of Individuals on Long-Term ART Contain Few Genetically Intact Proviruses   Detection of Identical Intact HIV-1 Proviruses in Participants on Long-Term ART   FLIPS Provides Advantages over Existing Assays that Genetically Characterize the Latent Reservoir We have developed a high-throughput and efficient method for genetically characterizing latent proviruses that overcomes the limitations of previous full-length sequencing assays and SPS.
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