Klara Sonnie Hinrichsmeyer on Muck Rack

Klara Sonnie Hinrichsmeyer

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Articles

mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapy - Nature Communications

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By Lisa Maria Riedmayr, Klara Sonnie Hinrichsmeyer, Michael Bartoschek, Christian Grimm Verified, Jan Wijnholds, Stefanie Fenske, Nanda Boon
| Nature Verified
Abstract Large genes including several CRISPR-Cas modules like gene activators (CRISPRa) require dual adeno-associated viral (AAV) vectors for an efficient in vivo delivery and expression. Current dual AAV vector approaches have important limitations, e.g., low reconstitution efficiency, production of alien proteins, or low flexibility in split site selection. Here, we present a dual AAV vector technology based on reconstitution via mRNA trans-splicing (REVeRT).
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mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapy

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By Lisa Maria Riedmayr, Klara Sonnie Hinrichsmeyer, Stefan Bernhard Thalhammer, Nina Karguth
| biorxiv.org
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