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Koay Teng Wei on Muck Rack

Koay Teng Wei

As seen in: Cell Press
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Articles

Mechanosensitive axon outgrowth mediated by L1-laminin clutch interface

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By Kouki Abe, Kentarou Baba, Liguo Huang, Koay Teng Wei
| Cell Press Verified
Abstract Mechanical properties of the extracellular environment modulate axon outgrowth. Growth cones at the tip of extending axons generate traction force for axon outgrowth by transmitting the force of actin filament retrograde flow, produced by actomyosin contraction and F-actin polymerization, to adhesive substrates through clutch and cell adhesion molecules. A molecular clutch between the actin filament flow and substrate is proposed to contribute to cellular mechanosensing.
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