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Kohei Kometani on Muck Rack

Kohei Kometani

As seen in: Nature, Cell Reports, The Journal of Immunology
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Articles

An iPSC-based in vitro model recapitulates human thymic epithelial development and multi-lineage specification - Nature Communications

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By Yann Pretemer, Takuya Yamamoto, Kohei Kometani, Akitsu Hotta
| Nature Verified
Abstract Thymic epithelial cells (TEC) are crucial in supporting T cell development, but their high heterogeneity and difficulty of isolation pose obstacles to their study in humans. Particularly, how diverse TEC lineages arise from a common progenitor remains poorly understood. To address this, here we establish a human iPSC-based model of thymus organogenesis capable of deriving these lineages in vitro.
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The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells

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By May Nakajima-Koyama, Mio Kabata, Joonseong Lee, Yuko Sogabe, Satoko Sakurai, Akira Hirota, Mizuki Kimura, Tomonori Nakamura, Yusuke Imoto, Kohei Kometani, Yoko Hamazaki, Yasuaki Hiraoka, Mitinori Saitou, Eisuke Nishida, Takuya Yamamoto
| Cell Reports Verified
ArticleOnline now115286Open access 1Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan 2Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa-Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan 3Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan 4Department of Anatomy and Cell Biology, Graduate...
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Bone Marrow Endothelial Cells Take Up Blood-Borne Immune Complexes via Fcγ Receptor IIb2 in an Erythropoietin-Dependent Manner

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By Takeshi Ito, Kohei Kometani, Nagahiro Minato, Yoko Hamazaki
| The Journal of Immunology Verified
Takeshi Ito, Kohei Kometani, Nagahiro Minato and Yoko Hamazaki J Immunol October 15, 2020, 205 (8) 2008-2015; DOI: https://doi.org/10.4049/jimmunol.1901101 Key Points FcγRIIb2 expression in BMECs is upregulated by Epo. Epo induces a capacity of incorporating soluble ICs selectively in BMECs. Epo promotes the clearance of soluble ICs in the blood circulation.
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