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Kol Jia Yong on Muck Rack

Kol Jia Yong

As seen in: Cell Reports
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Articles

Zinc Finger Protein SALL4 Functions through an AT-Rich Motif to Regulate Gene Expression

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By Nikki R. Kong, Jesse V. Kurland, Mahmoud A. Bassal, Kol Jia Yong
| Cell Reports Verified
Highlights • Transcription factor SALL4 binds an AT-rich DNA sequence • The C-terminal zinc finger cluster of SALL4 is responsible for DNA binding • SALL4 negatively regulates genes encoding histone 3 lysine 9-specific demethylases • SALL4 regulates heterochromatin through its repression of KDM genes Summary The zinc finger transcription factor SALL4 is highly expressed in embryonic stem cells, downregulated in most adult tissues, but reactivated in many aggressive cancers.
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