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Konstantin Barylyuk on Muck Rack

Konstantin Barylyuk

As seen in: Nature, PLOS Biology, BioRxiv, Cell Host & Microbe, eLife
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Articles

The spatial proteome of the Plasmodium falciparum schizont illuminates the composition and evolutionary trajectories of its organelles

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By Scott Chisholm, Víctor Flores, Alison Kemp, Lisa M. Breckels, Ludek Koreny, Konstantin Barylyuk, Anna Kuroshchenkova, Kathryn S. Lilley, Julian C. Rayner, Ross F. Waller
| Nature Verified
Abstract Malaria is caused by apicomplexan parasites of the genus Plasmodium, with all malaria symptoms and pathology caused by parasite stages that develop within, or transit between, host erythrocytes. The ability of Plasmodium cells to parasitise erythrocytes depends on distinctive intracellular compartments associated with invasion, as well as the development of unique cellular niches within the infected host cell.
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The non-canonical BAF chromatin remodeling complex is a novel target of spliceosome dysregulation in SF3B1-mutated chronic lymphocytic leukemia - Leukemia

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By Daniel Hägerstrand, Andreas Agathangelidis, Lydia Scarfò, Marine Armand, Neil E Kay, Lukas M Orre, Sarka Pospisilova, Konstantin Barylyuk, Mattias Vesterlund, Anton W. Langerak, Janne Lehtiö, Paolo Ghia, Kostas Stamatopoulos, Amrei Binzer-Panchal
| Nature Verified
Abstract SF3B1 mutations are recurrent in chronic lymphocytic leukemia (CLL), particularly enriched in clinically aggressive stereotyped subset #2. To investigate their impact, we conducted RNA-sequencing of 18 SF3B1MUT and 17 SF3B1WT subset #2 cases and identified 80 significant alternative splicing events (ASEs). Notable ASEs concerned exon inclusion in the non-canonical BAF (ncBAF) chromatin remodeling complex subunit, BRD9, and splice variants in eight additional ncBAF complex interactors.
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Apical annuli are specialised sites of post-invasion secretion of dense granules in Toxoplasma

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By Sara Chelaghma, Huiling Ke, Konstantin Barylyuk, Thomas Krueger
| eLife
Accepted manuscript, PDF only. Full online edition to follow. Author Accepted Manuscript PDF only version. The full online version will follow soon. Accepted Manuscript published January 25, 2024 (This version) Accepted December 5, 2023 Received November 15, 2023 Share this article Cite this article Apical annuli are specialised sites of post-invasion secretion of dense granules in Toxoplasma eLife 13:e94201.
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