Skip To Main Content
Krutika Ambani on Muck Rack

Krutika Ambani

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Krutika

Contact Krutika, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Rb-driven transcription limits its tumour-suppressive effects in breast cancer

|
By April C. Watt, Antonio Ahn, Catherine Blyth, Julia Dixon-Douglas, Rhiannon Coulson, Michael Taylor, Keefe Chan, Catherine Dietrich, Brendan Russ, Susanne Ramm, Kun-Hui Lu, Nichelle Pires, Ching-Seng Ang, Mark Dawson, Elgene Lim, Monica Arnedos, Sarat Chandarlapaty, Fabrice André, Shom Goel, Krutika Ambani, Christabella A. Mahendra, Jesus Garcia-Sannicolas, Olivia Voulgaris, Sheena Nunag
| Nature Verified
Abstract The retinoblastoma protein (Rb) is a tumour suppressor best known for repressing E2F transcription factors and halting cell cycle progression1. In hormone receptor-positive (HR+) breast cancer, CDK4/6 inhibitors activate Rb by preventing its phosphorylation, forming a key component of current endocrine therapy regimens2. How pharmacologically activated Rb remodels chromatin and influences transcription beyond cell cycle arrest remains poorly understood.
Open in Who Shared Issue with article?
See all 1 articles