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Catherine Blyth on Muck Rack

Catherine Blyth

As seen in: The London Standard, MSN UK, Yahoo Life, Daily Mail, Nature, The Guardian, The Mail on Sunday, The Telegraph, Yahoo Canada, Yahoo Sports Canada, Yahoo and
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Articles

Rb-driven transcription limits its tumour-suppressive effects in breast cancer

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By April C. Watt, Antonio Ahn, Catherine Blyth, Julia Dixon-Douglas, Rhiannon Coulson, Michael Taylor, Keefe Chan, Catherine Dietrich, Brendan Russ, Susanne Ramm, Kun-Hui Lu, Nichelle Pires, Ching-Seng Ang, Mark Dawson, Elgene Lim, Monica Arnedos, Sarat Chandarlapaty, Fabrice André, Shom Goel, Krutika Ambani, Christabella A. Mahendra, Jesus Garcia-Sannicolas, Olivia Voulgaris, Sheena Nunag
| Nature Verified
Abstract The retinoblastoma protein (Rb) is a tumour suppressor best known for repressing E2F transcription factors and halting cell cycle progression1. In hormone receptor-positive (HR+) breast cancer, CDK4/6 inhibitors activate Rb by preventing its phosphorylation, forming a key component of current endocrine therapy regimens2. How pharmacologically activated Rb remodels chromatin and influences transcription beyond cell cycle arrest remains poorly understood.
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The era when Britain locked up shoplifters, single mothers and ‘moral imbeciles’

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By Catherine Blyth
| Yahoo Verified
Is there any miscarriage of justice more grievous than a badly framed law? Historian Sarah Wise makes a powerful case for the prosecution in The Undesirables, a staggering study of 1913’s largely forgotten Mental Deficiency Act. Under its inhumane auspices, for almost half a century, tens of thousands of children and young adults disappeared, with little prospect of treatment or education. Their crime? In too many instances, to be classed “feeble-minded” or something new – a “moral imbecile”.
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Extraction and quantification of lineage-tracing barcodes with NextClone and CloneDetective

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By Givanna H Putri, Nadia M. Davidson, Catherine Blyth, Nichelle Pires
| BioRxiv
Abstract Summary: The study of clonal dynamics has significantly advanced our understanding of cellular heterogeneity and lineage trajectories. With recent developments in lineage-tracing protocols such as ClonMapper or SPLINTR, which combine DNA barcoding with single-cell RNA sequencing (scRNA-seq), biologists can trace the lineage and evolutionary paths of individual clones while simultaneously observing their transcriptomic changes over time.
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