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Ksenya Shchors on Muck Rack

Ksenya Shchors

As seen in: Cell Press
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Articles

Driving Neuronal Differentiation through Reversal of an ERK1/2-miR-124-SOX9 Axis Abrogates Glioblastoma Aggressiveness

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By Rebecca Petri, Hanna Sabelström, Ksenya Shchors
| Cell Press Verified
Highlights • Stem cell-derived glioma formation is accompanied by loss of neurogenesis • miR-124-dependent neuronal differentiation reduces glioblastoma (GBM) aggressiveness • An ERK1/2-miR-124-SOX9 axis regulates neuronal differentiation in GBM cells • An miR-124-induced neuronal phenotype sensitizes GBM cells to radiation Summary Identifying cellular programs that drive cancers to be stem-like and treatment resistant is critical to improving outcomes in patients.
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