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Kuglae Kim

As seen in: Nature, Cell Press
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Articles

Ubiquitin-mediated stabilization of KDM5B drives chemoresistance via repression of dual-specificity phosphatase 4 in ovarian cancer

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By Jung Eun Yoo, Yu Hyun Jeon, Jaewook Kim, Enzhi Luo, Sang Lee, Soo Oh Verified, Junjeong Choi, Kuglae Kim, So Hee Kwon
| Nature Verified
Abstract Despite advances in therapeutic regimens for managing cancer progression, ovarian cancer (OVC) still depends on platinum-based chemotherapy as its first-line treatment. Acquired resistance is accompanied by abnormal alterations in epigenetic regulation; however, in-depth mechanistic studies on cisplatin-resistant OVC are lacking.
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PLD1 is a key player in cancer stemness and chemoresistance: Therapeutic targeting of cross-talk between the PI3K/Akt and Wnt/β-catenin pathways - Experimental & Molecular Medicine

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By Kuglae Kim, Junjeong Choi
| Nature Verified
Abstract The development of chemoresistance is a major challenge in the treatment of several types of cancers in clinical settings. Stemness and chemoresistance are the chief causes of poor clinical outcomes. In this context, we hypothesized that understanding the signaling pathways responsible for chemoresistance in cancers is crucial for the development of novel targeted therapies to overcome drug resistance.
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Structural studies of serotonin receptor family

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By Kuglae Kim, Apeksha Parajulee
| bmbreports.org
Structural studies of serotonin receptor family Apeksha Parajulee & Kuglae Kim* Department of Pharmacy, College of Pharmacy, Yonsei University, Incheon 21983, Korea Correspondence to: Tel: +82-32-749-4530; Fax: +82-32-749-4105; E-mail: klkim@yonsei.ac.kr Received: July 27, 2023; Revised: September 1, 2023; Accepted: September 25, 2023; Published online: October 31, 2023. © Korean Society for Biochemistry and Molecular Biology. All rights reserved.
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