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Kuljeet Seehra on Muck Rack

Kuljeet Seehra

As seen in: BioRxiv, Cell Reports Medicine
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Articles

An intranasal adenoviral-vectored vaccine protects against highly pathogenic avian influenza H5N1 in naive and antigen-experienced animals

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By Baoling Ying, Kelly D. Pyles, Tamarand L. Darling, Kuljeet Seehra, Truc Lam Pham, Lin-Chen Huang, Houda H. Harastani, Ashish Sharma, Pritesh Desai, Elena A. Kashentseva, David Curiel, Bjoern Peters, James Case, Eva-Maria Strauch, Michael Diamond Verified, Adrianus Boon
| Cell Reports Medicine Verified
Keywords H5N1 influenza virus mucosal vaccine chimpanzee-adenovirus vector Syrian hamster clade 2.3.4.4b pre-existing immunity imprinting Introduction H5N1 avian influenza, a highly pathogenic strain of the influenza A virus (HPAI), poses a threat to the poultry and livestock industry and human public health.
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Inhibitors of membrane associated serine proteases block replication of coronavirus SARS-CoV-2 and influenza virus H1N1

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By Victoria Banas, Matthew Mahoney, Yevhenii A. Kyriukha, Kuljeet Seehra
| BioRxiv
Abstract TMPRSS2 is a membrane associated serine protease which is important in the viral pathogenesis of coronaviruses and influenza viruses. We developed mechanism-based covalent α-ketobenzothiazole (kbt) inhibitors using established substrate specificity PS-SCL screening of TMPRSS2 as a rational guide for inhibitor design. Three distinct focused libraries of tetrapeptide kbts were synthesized and evaluated for their inhibition of TMPRSS2, matriptase and other serine proteases.
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