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Baoling Ying on Muck Rack

Baoling Ying

As seen in: Nature, MDPI, Science Magazine, BioRxiv, Cell Press, Cell Reports Medicine, The Journal of Clinical Investigation
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Articles

Intranasal boosting induces variant-specific responses in SARS-CoV-2 vaccine-imprinted mice

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By Chieh-Yu Liang, Suzanne M. Scheaffer, James Case, Igor P. Dmitriev, Yuhao Li, Sameer Kumar Malladi, Xinyi Liu, Baoling Ying, Pritesh Desai, Sean Whelan Verified, David Curiel, Ali H Ellebedy, Michael Diamond Verified
| Nature Verified
Abstract The continued evolution of SARS-CoV-2 variants that evade immunity highlights a need to develop vaccines that elicit variant-specific antibodies and neutralize emerging strains. However, immune imprinting from antecedent SARS-CoV-2 exposure can limit the generation of such antibodies.
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An intranasal adenoviral-vectored vaccine protects against highly pathogenic avian influenza H5N1 in naive and antigen-experienced animals

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By Baoling Ying, Kelly D. Pyles, Tamarand L. Darling, Kuljeet Seehra, Truc Lam Pham, Lin-Chen Huang, Houda H. Harastani, Ashish Sharma, Pritesh Desai, Elena A. Kashentseva, David Curiel, Bjoern Peters, James Case, Eva-Maria Strauch, Michael Diamond Verified, Adrianus Boon
| Cell Reports Medicine Verified
Keywords H5N1 influenza virus mucosal vaccine chimpanzee-adenovirus vector Syrian hamster clade 2.3.4.4b pre-existing immunity imprinting Introduction H5N1 avian influenza, a highly pathogenic strain of the influenza A virus (HPAI), poses a threat to the poultry and livestock industry and human public health.
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Germinal center-mediated broadening of B cell responses to SARS-CoV-2 booster immunization

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By Sameer Kumar Malladi, Zhenghai Tang, Deepika Jaiswal, Baoling Ying
| Science Magazine Verified
Editor’s summary Booster vaccinations are key to maintaining immunity against evolving viral variants. The question remains whether protection against ancestral and descendant viruses depends on recalled memory B cells or the activation of naïve B cells. Malladi et al. investigated germinal center B cell dynamics in a cohort of participants who had received the bivalent SARS-CoV-2 mRNA booster vaccine targeting the ancestral strain and the Omicron subvariant.
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