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Articles by Kun Yan
Large language model driven multicenter prediction and explainable risk attribution of acute kidney injury
Abstract Acute kidney injury (AKI) represents a life-threatening condition among hospitalized patients, where early prediction enables prevention. Despite advances in existing models, clinical implementation remains hindered by excessive false positive rates (70%-94%) and lack of actionable clinical insights.
Development and Internal Validation of a Nomogram Model Discriminating Liver Metastases of Melanoma From Other Common Liver Metastases Based on the Combination of Conventional Ultrasonography and Contrast-enhanced Ultrasonography
ABBREVIATIONS 95% CI (95% confidence interval) AUC (area under the curve) AIC (Akaike information criterion) CEUS (contrast-enhanced ultrasonography) CT (computed tomography) DCA (decision curve analysis) DHGP (“desmoplastic” histopathological growth pattern) DICOM (digital imaging and communications in medicine) EPV (events-per-variable ratio) GEE (generalized estimating equations) HCC (hepatocellular carcinoma) ICC (intraclass correlation coefficient) LMM (liver metastases of melanoma) MRI...
l -Tartaric acid mitigates diabetic cardiac damage and is associated with changes in autophagy, apoptosis, and inflammatory markers
Abstract L-Tartaric acid is a white, crystalline organic acid commonly found in fruit, particularly grapes. The cardio-protective effects of L-Tartaric acid have been previously reported in multiple studies, but its effect on diabetic cardiomyopathy and its correlation with autophagy, apoptosis, and inflammation is still unclear. The purpose of the present study was to explore how L-Tartaric acid could be beneficial against cardiac failure in mice with diabetes.
Spin-valley-mismatched altermagnet for giant tunneling magnetoresistance
Abstract Altermagnet-based heterojunctions have demonstrated magnetoresistive effects in experiments, however, a predictive theoretical model for non-ferromagnetic structures has remained elusive. In this work, we develop a tunneling-based spin-transport theory that explicitly incorporates the transverse-wavevector (k∥)-dependent spin polarization of an altermagnet’s transport channels, enabling the prediction of giant tunneling magnetoresistance (TMR).
pH-Responsive 1,8-Naphthalimide Probe for a One-Step Loop-Mediated Isothermal Amplification Assay
Abstract Click to copy section linkSection link copied! Loop-mediated isothermal amplification (LAMP) has garnered significant interest as a promising technique for nucleic acid testing, especially in point-of-care and on-site applications, due to its rapid assay speed and simple operating conditions.
Laboratory evaluation of two insecticide-incorporated nets for the management of Prostephanus truncatus (Horn) (Coleoptera: Bostrichidae)
The invasive larger grain borer (Prostephanus truncatus) is a major pest of stored maize and threatens to expand its range under climate change. With the phase-out of methyl bromide and increasing resistance to phosphine, the most commonly used fumigant, there is a need for alternative management tactics.
Soil Acidification Decouples Microbial Biomass Production From Necromass Accumulation in Apple Orchards via Enhanced Mineral Association
Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description ldr70467-sup-0001-Figures.docxWord 2007 document , 5.3 MB Figure S1: Relationships of plant, soil, and microbial properties with soil pH. Blue represents microbial properties. Pale brown represents soil properties. Green represents plant properties.
Non‐Subtractive Arterial Spin Labeling‐Based (NSASL) Renal Magnetic Resonance Angiography (MRA): Development and Clinical Feasibility Evaluation
1 Introduction Accurate visualization of renal arteries is important for the diagnosis and management of conditions such as renal artery stenosis, embolism, aneurysm, tumors, and vascular insufficiency [1]. Contrast-enhanced (CE) computed tomography angiography (CTA) and magnetic resonance angiography (MRA) are widely used non-invasive clinical techniques for this purpose [2, 3].
Immunoglobulin levels of children with bronchiolitis obliterans syndrome after hematopoietic cell transplantation
ORIGINAL RESEARCH article Volume 12 - 2025 | https://doi.org/10.3389/fmed.2025.1692881 1 Introduction Bronchiolitis obliterans (BO) is characterized by persistent inflammation and fibrosis of the small airways, resulting in narrowing and/or complete occlusion of the airway lumen (1); ultimately, this condition may even lead to lung failure.
Developing a growing degree day model to guide integrated pest management of Eucosma giganteana, a pest of a novel perennial oilseed crop
Eucosma giganteana (Riley) (Lepidoptera: Tortricidae) is a specialist pest on Silphium spp. including Silphium integrifolium. This pest is currently one of the major limiting factors to the development and commercialization of S. integrifolium in Kansas as a more sustainable oilseed alternative within its native range. One of the factors making E. giganteana difficult to manage is the lack of knowledge about when pest management tactics should be applied for maximum effect.
The capacity of 3 stored product insect species to vector microbes after increasing dispersal periods
Prostephanus truncatus (Horn) (Coleoptera: Bostrichidae), Rhyzopertha dominica (F.) (Coleoptera: Bostrichidae), and Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae) are 3 important stored product pests of maize, but there has been little work evaluating how they vector microbes. While there has been some work assessing the microbial ecology of S. zeamais, none has directly assessed whether they transfer microbes to new food patches.
ZEB2 signaling is essential for ureteral smooth muscle cell differentiation and maintenance
Abstract Mowat-Wilson Syndrome (MWS) is a multiple congenital anomaly syndrome caused by mutations in the ZEB2, which plays a critical role in cell fate determination and differentiation during development. Congenital anomalies of the kidney and urinary tract (CAKUT) have been reported in MWS patients. However, the role of ZEB2 in urinary tract development and the cellular and molecular mechanism underlining the CAKUT phenotypes in MWS remains unknown.
Enhancing Adversarial Robustness through Stable Adversarial Training
1. Introduction Through continuous development, deep neural network modeling has been widely used in various fields, such as natural language processing, computer vision, signal processing, speech recognition, etc.
Modeling long-term, stage-structured dynamics of Tribolium castaneum (Coleoptera: Tenebrionidae) at food facilities with and without two types of long-lasting insecticide-incorporated netting
The movement and dispersal of insects have a significant impact on the integrated pest management (IPM) programs at food facilities. There are multiple ways that insects move around food facilities: one is through anthropogenic-mediated or insect-mediated means to and within a facility, and the other is natural immigration from the landscape. Prior work has shown that common stored product insects can be found and subsist on hosts found in the natural landscape (Jia et al.
Centralized feature pyramid‐based supervised deep learning for object detection model from GPR data
REFERENCES , , , , , et al. (2021) YOLOv4-5D: an effective and efficient object detector for autonomous driving. IEEE Transactions on Instrumentation and Measurement, 70, 1–13. , & (2022) YOLOX on embedded device with CCTV & TensorRT for intelligent multicategories garbage identification and classification. IEEE Sensors Journal, 22(16), 16522–16532. , , , , & (2021) RepVGG: making VGG-style ConvNets great again. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition.
Analysis of Runoff Changes and Their Driving Forces in the Minjiang River Basin (Chengdu Section) in the Last 30 Years
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Magnetic phase transitions in the triangular-lattice spin-1 dimer compound ${\mathrm{K}}_{2}{\mathrm{Ni}}_{2}{({\mathrm{SeO}}_{3})}_{3}$
In our study, we conduct magnetization and heat capacity measurements to investigate field-induced magnetic phase transitions within the newly synthesized compound K2Ni2(SeO3)3, a spin-1 dimer system arranged on a triangular lattice.
Flight capacity and behavior of Ephestia kuehniella (Lepidoptera: Pyralidae) in response to kairomonal and pheromonal stimuli
With few exceptions, most adult insects have a single pair of wings, while many have 2 pairs of wings (Marshall 2006). The prevalence of this appendage clearly indicates the importance of flight in mediating basic physiological functions such as fundamental interactions with the environment, potential mates, and other species. Flight in response to stimuli is one of the most basic behavioral responses by winged insects.
Emergent mobility edges and intermediate phases in one-dimensional quasiperiodic plasmonic chains
Anderson localization has been widely studied in low-dimensional aperiodic electronic, photonic, and acoustic systems. However, the disorder effect in the plasmonic system, where retardation and long-range couplings interact in complex ways, remains an open question. In this work, we investigate the localization properties of one-dimensional quasiperiodic plasmonic chains using the coupled dipole method and linearized Green's function.
Rational designs of polypropylene composite foam with open-cell structure via graphite conductive network for sound absorption
Rational designs of polypropylene composite foam with open-cell structure via graphite conductive network for sound absorption An exciting result is reported in this work. A polypropylene (PP) foam with a high open-cell content was achieved by constructing a thermally conductive network for the first time. PP and nano-graphite particles were used as substrate and filler, respectively, to prepare PP-graphite (PP-G) composite foam by twin-screw blending, hot pressing, and supercritical CO2 foaming.
Deep Learning Model Based on Multisequence MRI Images for Assessing Adverse Pregnancy Outcome in Placenta Accreta
Corresponding Author Ping Wang PhD School of Software and Microelectronics, Peking University, Beijing, China National Engineering Research Center for Software Engineering, Peking University, Beijing, China Key Laboratory of High Confidence Software Technologies (Peking University), Ministry of Education, Beijing, China Address reprint requests to: P.W., School of Software and Microelectronics; National Engineering Research Center for Software Engineering, Peking University; Key Laboratory of...
A Multi-Factor Combination Model for Medium to Long-Term Runoff Prediction Based on Improved BP Neural Network
4. Discussion 4.1. Comparison of Simulation Accuracy for Different Factor Quantities In order to further validate the reasonability and reliability of the selected factors for multi-factor combination runoff simulation prediction in the study area, we trained and built models using the top 9 and top 10 factors from the sensitivity analysis method (1980–2005).
Evaluation of Ecosystem Service Value of Homegarden in Chengdu Plain and Relevant Protection Strategy
3. Research Results 3.1. Quantity and Distribution of HGs In 2018, there were 71,892 HGs in Chengdu City (within the scope of Chengdu Plain) (Figure 6), with an average density of about 9.94 HGs/km2. The total area was 558.70 km2. The forest land and grassland area in HGs was 316.18 km2, accounting for 56.60% of the total HG area. The rural residential building and other land area was 242.52 km2, accounting for 43.41% of the total HG area.
Omni-Directional Capture for Multi-Drone Based on 3D-Voronoi Tessellation
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
A Multi-Target Detection Method Based on Improved U-Net for UWB MIMO Through-Wall Radar
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Coordinated Symmetrical Altitude Position and Attitude Control for Stratospheric Airship Subject to Strong Aerodynamic Uncertainties
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by 1, 1, 2,* and 2 1 College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China 2 College of Artificial Intelligence, Nankai University, Tianjin 300350, China * Author to whom correspondence should be addressed.
Activation of Nrf2 signalling pathway by tectoridin protects against ferroptosis in particulate matter‐induced lung injury
Abstract Background and Purpose Our previous research showed that ferroptosis plays a crucial role in the pathophysiology of PM2.5-induced lung injury. The present study aimed to investigate the protective role of the Nrf2 signalling pathway and its bioactive molecule tectoridin in PM2.5-induced lung injury by regulating ferroptosis.
High cost of waste treatment calls for systematic rethinking: A case study for a chemical industrial park in China
Abstract The chemical industry has witnessed a heavy global environmental clean-up and remediation burden. Chemical industrial parks (CIPs) are important carriers of the chemical industry and present both opportunities and challenges in terms of environmental sustainability.
Comparing the effectiveness of type of the traditional Chinese exercises, frequency, intensity, time in osteoporosis: a protocol for systematic evaluation and network meta-analysis of randomised controlled trials
Methods This study protocol will be presented in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for the Protocol.28 This protocol is registered with PROSPERO under registration number CRD42022323622. Eligibility criteria Inclusion criteria: We will use the Population, Intervention, Outcome and Study design principle to evaluate the studies (table 1). Exclusion criteria: Studies meeting any of the following conditions will be excluded.
Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5 - Nature Cancer
Abstract The most lethal subtype of diffuse intrinsic pontine glioma (DIPG) is H3K27M. Although ACVR1 mutations have been implicated in the pathogenesis of this currently incurable disease, the impacts of bone morphogenetic protein (BMP) signaling on more than 60% of H3K27M DIPG carrying ACVR1 wild-type remain unknown. Here we show that BMP ligands exert potent tumor-suppressive effects against H3.3K27M and ACVR1 WT DIPG in a SMAD-dependent manner.
A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells - Nature Communications
Abstract TGF-β family proteins including Nodal are known as central regulators of early development in metazoans, yet our understanding of the scope of Nodal signaling’s downstream targets and associated physiological mechanisms in specifying developmentally appropriate cell fates is far from complete.
Multifunctional metal-biopolymer coordinated double network hydrogel combing of multi-stimuli responsiveness, self-healing, shape memory and antibacterial properties
Multifunctional metal-biopolymer coordinated double network hydrogel combing of multi-stimuli responsiveness, self-healing, shape memory and antibacterial properties Outfitted with abundant hydrogen bonding and coordination active groups, carboxymethyl chitosan (CMC) possesses a class of naturally occurring ligands for coordination with metal ions indicating great possibilitiies in various areas.
Inkjet-printed porous polyaniline gel as an efficient anode for microbial fuel cells
Future application of microbial fuel cells (MFCs) requires a high-throughput and more convenient pathway to manufacture high-performance anodes. In this research, inkjet-printed PANI gel on carbon paper was first fabricated and was successfully employed as anodes in MFCs. Thanks to the inkjet-printing technology, such anodes can be easily produced in large quantities.
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