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Shanshan Yin on Muck Rack

Shanshan Yin

As seen in: Environmental Health Perspectives, British Journal of Cancer, Nature, Wiley Online Library, Frontiers, MDPI, ACS Publications, Archives of Public Health, Cell Press, Stem Cell Reports and
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Articles

Machine learning prediction of bile salt export pump inhibition with Boruta feature selection in imbalanced data

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By Bailang Liu, Yong Liu, Hui Yang, Shanshan Yin, Junnan Wang, Zhikui Cheng, Xin Zhao, Xuejun Zhang, Shu Xiang Li, Lifei Liu
| Frontiers
Abstract Introduction: Bile salt export pump (BSEP) inhibition is an important mechanistic risk factor for cholestatic drug-induced liver injury. Quantitative structure-activity relationship (QSAR) models may support early safety screening, but practical BSEP datasets are often limited in size and imbalanced. Methods: We evaluated a machine-learning workflow combining molecular descriptors and fingerprints, Boruta feature selection, and class-imbalance training.
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Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling that associates with impaired function of neighboring T cells

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By Armin Gandhi, Kathryn Lande, Kelly Li, Michael LaPorte, K. Garrett Evensen, Marcos Garcia Teneche, Rouven Arnold, Adarsh Rajesh, Jessica Proulx, Shanshan Yin, Aaron Havas, Angela Y. Liou, Allen Lee, Helene Martini, Xue Lei, Charlene Miciano, Qian Yang, Sainath Mamde, Andrew Davis, Rebecca A. Porritt, Alessandra Sacco, João F. Passos, Kevin Tharp, Kevin Y. Yip, Allen Wang, Bing Ren, April Williams, Susan M Kaech, Peter Adams, Filipe A. Hoffmann, Shirong Tan, Benji Portillo, Elizabeth W. Smoot
| Nature Verified
Abstract Liver cancer incidences increase dramatically beyond 55 years of age, suggesting that age-associated changes contribute critically to tumor initiation. However, the mechanisms linking liver aging and cancer initiation remain incompletely defined. This study investigated the role of CD44, a marker of liver tumor-initiating cells (TICs), in age-associated liver pathophysiology.
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Development and Internal Validation of a Nomogram Model Discriminating Liver Metastases of Melanoma From Other Common Liver Metastases Based on the Combination of Conventional Ultrasonography and Contrast-enhanced Ultrasonography

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By Yuanyuan Xu, Hao Wu, Haijing Tian, Hewen Tang, Yue Cong, Shanshan Yin, Wei Yang, Kun Yan, Wei Wu
| Academic Radiology Verified
ABBREVIATIONS 95% CI (95% confidence interval) AUC (area under the curve) AIC (Akaike information criterion) CEUS (contrast-enhanced ultrasonography) CT (computed tomography) DCA (decision curve analysis) DHGP (“desmoplastic” histopathological growth pattern) DICOM (digital imaging and communications in medicine) EPV (events-per-variable ratio) GEE (generalized estimating equations) HCC (hepatocellular carcinoma) ICC (intraclass correlation coefficient) LMM (liver metastases of melanoma) MRI...
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