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Kusum K. Singh

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Exon Junction Complexes Suppress Spurious Splice Sites to Safeguard Transcriptome Integrity

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By Volker Boehm, Thiago Britto-Borges, Anna-Lena Steckelberg, Kusum K. Singh
| Cell Press Verified
Productive splicing of human precursor messenger RNAs (pre-mRNAs) requires the correct selection of authentic splice sites (SS) from the large pool of potential SS. Although SS consensus sequence and splicing regulatory proteins are known to influence SS usage, the mechanisms ensuring the effective suppression of cryptic SS are insufficiently explored.
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