Kyaw Min Aung

Method details Animal experiments To monitor in vivo Ifnb1 gene expression level, Ifnb1 luciferase reporter mice, Ifnb+/Δβ-luc and IfnbΔβ-luc/Δβ-luc were used. To monitor in vivo viral replication, herpes simplex virus type I strain KOS KOS/Dlux/OriL (HSV-I-luc) containing a firefly luciferase reporter ( ), vesicular stomatitis virus VSV-AV2 (), and VSV-GFP ( Nair et al., 2014 Nair S. Michaelsen-Preusse K. Finsterbusch K. Stegemann-Koniszewski S. Bruder D. Grashoff M. Korte M. Köster M. Kalinke U.

Abstract Colorectal cancer is one of the leading causes of cancer‐related death worldwide. The adenomatous polyposis coli (APC) gene is mutated in hereditary colorectal tumors and in more than 80% of sporadic colorectal tumors. APC mutations impair β‐catenin degradation, leading to its permanent stabilization and increased transcription of cancer‐driving target genes.