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Articles by Kyle Smith
Serial assessment of measurable residual disease in medulloblastoma liquid biopsies
Highlights • Biomarkers for response monitoring are lacking in medulloblastoma • CSF-derived cfDNA profiling captures chromosomal landscapes of primary tumors • Detectability of CNVs in cfDNA carries clinical utility as an MRD biomarker • Liquid biopsy analyses should be incorporated into future medulloblastoma trials Summary Nearly one-third of children with medulloblastoma, a malignant embryonal tumor of the cerebellum, succumb to their disease.
Sleep Duration Correlates With Performance in Ultra-Endurance Triathlon
1. TroynikovO, WatsonCG, NawazN. Sleep environments and sleep physiology: a review. J Therm Biol. 2018;78(April):192–203. doi: Crossref PubMed Troynikov O, Watson CG, Nawaz N . Sleep environments and sleep physiology: a review . J Therm Biol. 2018;78(April):192–203. doi: 10.1016/j.jtherbio.2018.09.012 30509635 )| false Search Google Scholar Export Citation 2. LasselinJ, RehmanJU, ÅkerstedtT, LekanderM, AxelssonJ.
Predicting Chronic Wound Healing Time using Machine Learning to Support Real-Time Clinical Decisions
Abstract <b>Objective</b>:
Chronic wounds have risen to epidemic proportions in the United States and can have an emotional, physical, and financial toll on patients. By leveraging data within the electronic health record (EHR), machine learning models offer the opportunity to facilitate earlier identification of wounds at risk of not healing or healing after an abnormally long time, which may improve treatment decisions and patient outcomes.
Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children’s Oncology Group
Visual Abstract. Efficacy of Carboplatin and Isotretinoin in Children With High-Risk Medulloblastoma Figure 1. All 294 Patients With Medulloblastoma Enrolled in the Children’s Oncology Group ACNS0332 Study aSecond randomization to isotretinoin maintenance included 56 patients in the arm without carboplatin and 58 patients in the arm with carboplatin before closure of the isotretinoin randomization based on futility analysis.
Cooperative Communication with Humans Evolved to Emerge Early in Domestic Dogs
Highlights • Dog puppies are more attracted to humans than wolf puppies raised by humans • Dog puppies use human gestures and make eye contact more than wolf puppies • Both species perform similarly on memory and inhibitory control tasks • Dogs’ early emerging social skills demonstrate domestication’s effect on cognition Summary 1 Belyaev D.K. Plyusnina I.Z. Trut L.N. Domestication in the silver fox (Vulpes fulvus Desm): Changes in physiological boundaries of the sensitive period of primary...
Gastrointestinal pathophysiology during endurance exercise: endocrine, microbiome, and nutritional influences
Ashton T, Young IS, Davison GW, Rowlands CC, McEneny J, Van Blerk C, Jones E, Peters JR, Jackson SK (2003) Exercise-induced endotoxemia: the effect of ascorbic acid supplementation. Free Radic Biol Med 35(3):284–291. https://doi.org/10.1016/s0891-5849(03)00309-5 CAS Article PubMed Google Scholar Beaulieu K, Olver TD, Abbott KC, Lemon PWR (2014) Energy intake over 2 days is unaffected by acute sprint interval exercise despite increased appetite and energy expenditure.
Children's Oncology Group Phase III Trial of Reduced-Dose and Reduced-Volume Radiotherapy With Chemotherapy for Newly Diagnosed Average-Risk Medulloblastoma | Journal of Clinical Oncology
PURPOSE Children with average-risk medulloblastoma (MB) experience survival rates of ≥ 80% at the expense of adverse consequences of treatment. Efforts to mitigate these effects include deintensification of craniospinal irradiation (CSI) dose and volume. METHODS ACNS0331 (ClinicalTrials.gov identifier: NCT00085735) randomly assigned patients age 3-21 years with average-risk MB to receive posterior fossa radiation therapy (PFRT) or involved field radiation therapy (IFRT) following CSI.
Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma
Medulloblastoma relapse represents a key determinant of cancer-related mortality in the pediatric population.1,2 Multimodal therapy that incorporates maximal surgical resection with craniospinal irradiation (CSI; children older than 3 years) and chemotherapy has driven 5-year overall survival rates to 80%-85% for average-risk disease and 60%-70% for high-risk disease.3,4 Nevertheless, treatment failure and relapse occur in up to one-third of patients and confers abysmal prognosis, with only...
Essential Science: Science makes beer last longer
To help to extend how long a bottle or can of beer might last for, food scientists from China have genetically engineered a lager yeast so that the fungus produces a greater abundance of molecules. A local dove enjoying some "Mythos" Hellenic lager. The street life of Athens is incredibly lively and vibrant. A further difference with wine and beer, is that wine tends to improve with age, whereas beer deteriorates.
What Defines the Good Person? Cross-Cultural Comparisons of Experts' Models With Lay Prototypes
Aarts, H. , & Dijksterhuis, A. (2000). Habits as knowledge structures: Automaticity in goal-directed behavior . Journal of Personality & Social Psychology, 78, 53-63 . Google Scholar | Crossref | Medline | ISI Bamberg, S. , & Schmidt, P. (2003). Incentives, morality, or habit? Predicting students' car use for university routes with the models of Ajzen, Schwartz and Triandis . Environment and Behavior, 35, 264-285 . Google Scholar | SAGE Journals | ISI Bardi, A. , & Schwartz, S.H. (2003).
Unraveling the origin of chirality from plasmonic nanoparticle-protein complexes
Report Qingfeng Zhang1,2, Taylor Hernandez1, Kyle W. Smith1,*, Seyyed Ali Hosseini Jebeli3, Alan X. Dai4, Lauren Warning1, Rashad Baiyasi3, Lauren A. McCarthy1, Hua Guo5, Dong-Hua Chen6, Jennifer A. Dionne7, Christy F. Landes1,2,3,†, Stephan Link1,2,3,† 1Department of Chemistry, Rice University, Houston, TX, USA. 2Smalley-Curl Institute, Rice University, Houston, TX, USA. 3Department of Electrical and Computer Engineering, Rice University, Houston, TX, USA.
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