Kyran Wissink on Muck Rack

Kyran Wissink

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Articles

Systematic benchmarking demonstrates large language models have not reached the diagnostic accuracy of traditional rare-disease decision support tools | European Journal of Human Genetics

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By Justin Reese, Leonardo Chimirri, Yasemin Bridges, Daniel Danis, J. Harry Caufield, Michael Gargano, Fengchen Liu, Kyran Wissink, Julie McMurry, Enock Niyonkuru, Daniel Korn, Elena Casiraghi, Giorgio Valentini, Melissa Haendel, Damian Smedley, Christopher Mungall, Peter Robinson Verified, Carlo Kroll, Andrew Schmeder, Adam S. L. Graefe, Julius O. B. Jacobsen
| Nature Verified
Abstract Large language models (LLMs) show promise in supporting differential diagnosis, but their performance is challenging to evaluate due to the unstructured nature of their responses, and their accuracy compared to existing diagnostic tools is not well characterized.
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Frequent genetic exchange shapes the pan-mitogenome of the fungal plant pathogen Fusarium oxysporum

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By Anouk van Westerhoven, Jelmer Dijkstra, Luis Aznar Palop, Kyran Wissink
| biorxiv.org
Abstract Mitochondria are present in almost all eukaryotic lineages. The mitochondrial genomes (mitogenomes) evolve separately from nuclear genomes, and they can therefore provide relevant insights into the evolution of their host species. Fusarium oxysporum is a major fungal plant pathogen that is assumed to reproduce clonally. However, horizontal chromosome transfer between strains can occur through heterokaryon formation, and recently signs of sexual recombination have been observed.
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