Lacy J. Barton

Abstract Juvenile hormone (JH) is one of the most essential hormones controlling insect metamorphosis and physiology. While it is well known that JH affects many tissues throughout the insect life cycle, the difference in JH responsiveness and the repertoire of JH-inducible genes among different tissues has not been fully investigated. In this study, we monitored JH responsiveness in vivo using transgenic Drosophila melanogaster flies carrying a JH response element-GFP (JHRE-GFP) construct.

Highlights • Juvenile hormones are necessary and sufficient for primordial germ cell migration • JH signaling is active in and around migrating PGCs prior to endocrine function • Compensatory feedback sensitive to JH receptor function maintains JH homeostasis • JH-like retinoic acids may have similar roles during mammalian germ cell migration Summary Germ cells are essential to sexual reproduction.

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