Lael Barlow

Van Acker Z.P. Bretou M. Annaert W. Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: Impact of genetic risk factors. Mol. Neurodegener. 2019; 14: 20 Howell G.J. Holloway Z.G. Cobbold C. Monaco A.P. Ponnambalam S. Cell biology of membrane trafficking in human disease. Int. Rev. Cytol. 2006; 252: 1-69 Pantazopoulou A. Glick B.S. A kinetic view of membrane traffic pathways can transcend the classical view of Golgi compartments. Front. Cell Dev. Biol. 2019; 7: 153 Sztul E.

At the intersection of the secretory and endocytic membrane-trafficking pathways in eukaryotes lies the Golgi. This organelle comprises a series of compartments termed cisternae, providing a platform for protein transport, glycosylation, and targeting. The Golgi is crucially important for normal cellular function, as demonstrated by the myriad diseases that result when genes associated with it are mutated [1].

One of the most recognizable structures inside eukaryotic cells, such as human and plant cells, is the Golgi apparatus. This organelle comprises a series of membrane-bound compartments that are tightly stacked together, like a stack of pancakes. These Golgi compartments, also termed cisternae, process and sort proteins that are synthesized at the endoplasmic reticulum and destined for other organelles or the cell’s external environment.