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Laising Yen on Muck Rack

Laising Yen

As seen in: Frontiers
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Articles

Newly discovered circRNAs encoding proteins: recent progress

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By Yuan Zhou, Fengbiao Mao, Laising Yen
| Frontiers
1 Introduction Scientists first discovered circular RNA (circRNA) in plant viruses, yeast mitochondrial RNA and hepatitis B virus (Sanger et al., 1976; Arnberg et al., 1980; Kos et al., 1986). Different from the production of traditional linear RNA, circRNA is a new type of RNA molecule produced by back-splicing of pre-mRNA.
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RNA-mediated gene fusion in mammalian cells

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By Sachin Gupta Verified, Liming Luo, Laising Yen
| PNAS Verified
This report provides striking evidence that expression of a chimeric RNA mimicking a fusion RNA can drive the formation of gene fusions in mammalian cells. However, it is the antisense rather than sense chimeric RNAs that effectively drive gene fusion.
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