Citation: Nguyen CTK, Pham LT, Le MH, Le DH, Vu MN (2025) The relationship between serum eosinophil peroxidase and major basic protein levels in relation to severity and response to H1 antihistamines in chronic spontaneous Urticaria. PLoS One 20(11): e0336118. https://doi.org/10.1371/journal.pone.0336118 Editor: Ping Xiang, Central South University, CHINA Received: July 24, 2025; Accepted: October 21, 2025; Published: November 11, 2025 Copyright: © 2025 Nguyen et al.