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Latasha Little

As seen in: Nature
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Articles

Decreased TXNRD1 is associated with resistance to tagraxofusp in blastic plasmacytoid dendritic cell neoplasms, as seen in phase II

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By Hannah C. Beird, Sankaranarayanan Kannan, Jingjing Liu, Janice Chen, Poonam Desai, Tianyu Cai, Lina Han, Jennifer L. Cotton, Sandeep Singh, Saurabh Gupta Verified, Latasha Little, Marcos R Estecio, Xingzhi Song, Hussein Abbas, Jianhua Zhang, Curtis Gumbs, Christopher Brooks, Hagop Kantarjian, Michael Andreeff, Marina Konopleva, P. Andrew Futreal, Naveen Pemmaraju, Arturo Olguin
| Nature Verified
Abstract Tagraxofusp is a CD123-targeted therapy comprised of a recombinant human interleukin-3 (IL-3) fused to a truncated diphtheria toxin payload. It is the first approved treatment specifically for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN).
Open in Who Shared Issue with article?

Germline variants in cancer susceptibility genes among patients with mucosal melanoma

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By Afsaneh Amouzegar, Xiaogang Wu, James Long, Gabriela Chen, Justin Wong, Curtis Gumbs, Jared C. Malke, Julie Simon, Jianhua Zhang, Priyadharsini Nagarajan, michael davies, Hussein Tawbi, Rodabe N. Amaria, Alexandra Ikeguchi, Shirley Y Su, Ehab Hanna, Roi Weiser, Brian K. Bednarski, Travis Sims, Devarati Mitra, Jennifer Wargo, Jeffrey E. Gershenwald, Paul Scheet, Yao Yu, Kelly Nelson, Jennifer McQuade, P. Andrew Futreal, Sabitha Prabhakaran, Latasha Little, Neus Bota, Isabella C. Glitza Oliva, Chad Huff
| Nature Verified
Abstract Mucosal melanoma (MM) is a rare and aggressive melanoma subtype with poor outcomes and poorly understood risk factors, including the contribution of germline pathogenic variants (PVs). In this study, 346 MM patients treated at MD Anderson Cancer Center underwent germline sequencing of 322 known cancer susceptibility genes, with PV frequencies compared to population controls (gnomAD and TOPMed) using Fisher’s exact test.
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