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Laura Baranello on Muck Rack

Laura Baranello

As seen in: Nature, Science Magazine, Cell Press
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Articles

Epigenetic control of topoisomerase 1 activity presents a cancer vulnerability - Nature Communications

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By Tae-Hee Lee, Xianzhen Zhou, David Corujo, Marcus Buschbeck, Laura Baranello
| Nature Verified
Abstract DNA transactions introduce torsional constraints that pose an inherent risk to genome integrity. While topoisomerase 1 (TOP1) activity is essential for DNA supercoil removal, the aberrant stabilization of TOP1:DNA cleavage complexes (TOP1ccs) can result in cytotoxic DNA lesions. What protects genomic hot spots of topological stress from excessive TOP1cc accumulation remains unknown. Here, we identify chromatin context as an essential means to coordinate TOP1cc resolution.
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Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response

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By Joshua Porter, Brian Fisher, Laura Baranello, Julia Liu
| Cell Press Verified
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page. Online Now Article ArticleGlobal Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response, , , Julia C. LiuxJulia C.
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RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription

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By Laura Baranello, Damian Wojtowicz, Kairong Cui, Ballachanda N. Devaiah, Hye-Jung Chung
| Cell Press Verified
Figure S4TOP1 Stimulation Parallels the Level of RNAPII Phosphorylation, Related to Figures 4 and 5(A) Increasing amounts of hypo-phosphorylated (RNAPIIA) and highly phosphorylated (RNAPIIO) RNAPII were co-incubated with TOP1 before the addition of plasmid substrate. After relaxation, DNA was run under native conditions. Numbers represent quantification of relaxed fraction. SC, supercoiled band. R, relaxed band. N, nicked band.(B) Left, flowchart.
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