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Laura Barreyro on Muck Rack

Laura Barreyro

As seen in: The Journal of Clinical Investigation
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Articles

Ubiquitin-conjugating enzyme UBE2N modulates proteostasis in immunoproteasome-positive acute myeloid leukemia

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By Chiharu Ishikawa, Laura Barreyro, Avery Sampson, Kathleen Hueneman
| The Journal of Clinical Investigation
Abstract Altered protein homeostasis through proteasomal degradation of ubiquitinated proteins is a hallmark of many cancers. Ubiquitination, coordinated by E1, E2, and E3 enzymes, involves up to 40 E2-conjugating enzymes in humans to specify substrates and ubiquitin linkages. In a screen for E2 dependencies in acute myeloid leukemia (AML), ubiquitin conjugating enzyme E2 N (UBE2N) emerged as the top candidate.
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