Keywords Animals, Butyrates, Fatty Acids, Volatile, Gastrointestinal Microbiome, Inflammation, Mice, Monocarboxylic Acid Transporters, Tears, Corneal diseases, Microbiome, Conjunctival diseases Abstract Dry eye is a common ocular inflammatory disorder characterized by tear film instability and reduced tear production. There is increasing evidence that homeostasis of the ocular surface is impacted by the intestinal microbiome.