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Lauren Baracco on Muck Rack

Lauren Baracco

As seen in: PNAS, Science Magazine, BioRxiv
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Articles

The mammalian SKI complex is a broad-spectrum antiviral drug target that upregulates cellular cholesterol to inhibit viral replication

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By Stuart Weston, Lauren Baracco, Louis Taylor, Alison Scott
| BioRxiv
Abstract There is a need for the development of broad-spectrum antiviral compounds that can act as first line therapeutic countermeasures to emerging viral infections. Host-directed approaches present a promising avenue of development and carry the benefit of mitigating risks of viral escape mutants. We have previously found the SKI (super killer) complex to be a broad-spectrum, host-target with our lead compound ("UMB18") showing activity against influenza, coronaviruses, and filoviruses.
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Comparative Analysis of SARS-CoV-2 Antigenicity across Assays and in Human and Animal Model Sera

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By Barbara Mühlemann, Samuel Hedley Wilks, Lauren Baracco, Meriem Bekliz
| BioRxiv
Abstract The antigenic evolution of SARS-CoV-2 requires ongoing monitoring to judge the immune escape of newly arising variants. A surveillance system necessitates an understanding of differences in neutralization titers measured in different assays and using human and animal sera. We compared 18 datasets generated using human, hamster, and mouse sera, and six different neutralization assays. Titer magnitude was lowest in human, intermediate in hamster, and highest in mouse sera.
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SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer’s-like neuropathology

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By Wei-Bin Shen, James E. Logue, Penghua Yang, Lauren Baracco
| BioRxiv
New Results Wei-Bin Shen, James Logue, Penghua Yang, Lauren Baracco, Montasir Elahi, E. Albert Reece, Bingbing Wang, Ling Li, Thomas G Blanchard, View ORCID ProfileZhe Han, Matthew B Frieman, View ORCID ProfileRobert A Rissman, Peixin Yang doi: https://doi.org/10.1101/2022.01.31.478476 Abstract Major cell entry factors of SARS-CoV-2 are present in neurons; however, the neurotropism of SARS-CoV-2 and the phenotypes of infected neurons are still unclear.
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