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Articles by Lauren Ely
The impact of lexical specificity training on at-risk emergent bilinguals
The impact of lexical specificity training on at-risk emergent bilinguals Autores: Miao Li, Catherine E. Snow, Lauren Ely, Jan C. Frijters, Esther Geva, Becky Xi Chen Localización: Applied psycholinguistics, ISSN 0142-7164, Vol. 44, Nº 5, 2023, págs.
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells
Highlights • Crystal structure of the complete IL-23 receptor complex • Cryo-EM maps of the complete IL-12 and IL-23 receptor complexes • The p40 subunit of IL-12 and IL-23 is a common gateway for induction of STAT signaling • T-cell-biased IL-12 agonists elicit anti-tumor response without inducing toxicity Summary Interleukin-12 (IL-12) and IL-23 are heterodimeric cytokines that are produced by antigen-presenting cells to regulate the activation and differentiation of lymphocytes, and they...
A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism
Interleukin-2 (IL-2) has been shown to suppress immune pathologies by preferentially expanding regulatory T cells (T ). However, this therapy has been limited by off-target complications due to pathogenic cell expansion. Recent efforts have been focused on developing a more selective IL-2. It is well documented that certain anti-mouse IL-2 antibodies induce conformational changes that result in selective targeting of T .
Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent
Crystal Structure of the DEF Fab Bound to the Human FXIa Protease Domain Co-crystal Structure Predicts and Accounts for DEF Specificity and Binding Properties Use of FXIaiPD as a Decoy to Reverse Effects of DEF on FXIa Enzymatic Activity FXIaiPD Blocks the Ability of DEF to Inhibit FXIIa-Driven Thrombin Generation in Human Plasma FXIaiPD Does Not Bind the FXIa Substrate FIX or Alter Thrombin Generation in Human Plasma in the Absence of DEF FXIaiPD Reverses Effects of DEF in an In Vivo Rabbit...
Former NFL wide receiver considers coaching career
Nearly three years after catching his last NFL pass, Mike Sims-Walker was trying to rekindle a dream. That was why the former Edgewater and UCF wide receiver was trying out for the Cleveland Browns in April, attempting to show that some of the talent that allowed him to catch 134 passes over five NFL seasons, mostly with the Jacksonville Jaguars, still flickered. Sims-Walker's ability wasn't the issue. His knees, which have endured seven surgeries, were.
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