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Articles by Le Gall
Triskellines A (3,6,8-Trisubstituted [1,2,4]triazolo[4,3- b ]pyridazines) as Potent Antagonists of Human Adenosine Receptor A3
Adenosine receptor A3 (A3AR) is coupled to Gi proteins, leading to adenylate cyclase inhibition, and to Go proteins, leading to phospholipase C activation and Ca++ release. We here describe the synthesis and biological characterization of a family of 3,6,8-trisubstituted [1,2,4]-triazolo-[4,3-b]-pyridazines (Triskellines A), initially inspired from the cyclin-dependent kinase inhibitory purine (R)-Roscovitine. Triskellines A act as selective A3AR antagonists.
Una contextualización de las ideas filosóficas de Richard Routley/Sylvan en la historia de los desarrollos de la ética ambiental
Ayuda Buscar en la ayuda Buscar en la ayuda Una contextualización de las ideas filosóficas de Richard Routley/Sylvan en la historia de los desarrollos de la ética ambiental Le Gall, Sylvain [1] [1] Ministère de l’Éducation Nationale, de l’Enseignement Supérieur et de la Recherche Localización: Yachay: Revista de Cultura, Filosofía y Teología, ISSN 1016-8257, Nº. 82, 2025 (Ejemplar dedicado a: Revista Yachay n° 82), págs.
Triazenes as inhibitors of HIV-1 and HCoV-OC43: A structure-activity relationship study
Mérindol, N., Hashemian, S. M., Sokhna, S., Girard, M.-P., Presset, M., Seck, I., Ba, L. A., Ka, S., Ndoye, S. F., Samb, I., Le Gall, E., Berthoux, L., Seck, M. et Desgagné-Penix, I. (2025). Triazenes as inhibitors of HIV-1 and HCoV-OC43: A structure-activity relationship study. European Journal of Medicinal Chemistry Reports, 15 . Article 100288. ISSN 2772-4174 DOI 10.1016/j.ejmcr.2025.100288 PDF Disponible sous licence Creative Commons Attribution Non-commercial.
Characterization of Titan's Northern Polar Terrains from Inversion of Cassini RADAR Data
Published December 25, 2025 | Version Published Journal Article Metadata-only Mastrogiuseppe, M.1 Poggiali, V.2 Raguso, M. C.3 Fileti, A.4 Le Gall, A.5 Wall, S.3 Lopes, R.6 Hayes, A.2 Lunine, J.3 Elachi, C.3 1. Link Campus University 2. Cornell University 3. California Institute of Technology 4. Dipartimento di Ingegneria dell'Informazione, Elettronica e Telecomunicazioni (DIET), La Sapienza Università di Roma, Rome, Italy 5. French National Centre for Scientific Research 6.
Combining spring wheat genotypes with contrasting root architectures modifies plant–microbe interactions under different water regimes - Plant and Soil
Abstract Improving agricultural tolerance to climate change is crucial for food security. We investigated whether combining wheat genotypes with contrasting root architecture enhances plant performance under varying conditions. Specifically, we examined how these genotype mixtures affect nitrogen uptake, carbon release and root-microbe interactions compared to single-genotype plantings.
Effects of the urinary urea excretion index on the decision to wean ICU patients with acute kidney injury from renal replacement therapy: a before-after multicentre study (D-STOP) | Critical Care | Full Text
In total, 179 (58%) and 130 (42%) patients were included in the before and after cohorts, respectively (Fig. 2. flow chart). The most frequent exclusions were patients who were anuric (≤ 100 mL/d urine output) from RRT initiation to death, discharge from the ICU, or 28 days from the insertion of a catheter. No data were missing.
Tecnología, equidad y aprendizaje: un análisis de la inclusión y exclusión educativa en la enseñanza universitaria mediada por TIC
Ayuda Buscar en la ayuda Buscar en la ayuda Tecnología, equidad y aprendizaje: un análisis de la inclusión y exclusión educativa en la enseñanza universitaria mediada por TIC Oscar Alberto Estigarribia [1] ; Luis Justo Le Gall [1] ; Rubén Alberto Morenate [1] [1] Universidad Nacional de Misiones, Posadas, Misiones, Argentina Localización: Revista de Educación: Argentina, ISSN 1853-1318, ISSN-e 1853-1326, Nº. 35, 1 (Dossier), 2025, págs.
A monoclonal anti-hemagglutinin stem antibody modified with zanamivir protects against both influenza A and B viruses
Contributed by Hidde L. Ploegh; received November 27, 2024; accepted March 1, 2025; reviewed by Pamela J. Bjorkman, Antonio Lanzavecchia, and Rino Rappuoli Get full access to this article Purchase, subscribe or recommend this article to your librarian. Data, Materials, and Software Availability All data generated in this study are included and directly available in the article and/or SI Appendix. Acknowledgments We thank BEI Resources for providing us with the influenza viruses used for this study.
Neutrophils Display Novel Partners of Cytosolic Proliferating Cell Nuclear Antigen Involved in Interferon Response in COVID-19 Patients
Keywords: Neutrophils, Proliferating cell nuclear antigen, Interferon, PAD4, Histone 3, COVID-19 Keywords: Neutrophils, Proliferating cell nuclear antigen, Interferon, PAD4, Histone 3, COVID-19 Neutrophils are crucial in host defense and have been recognized for decades for their central role in containing infections [1].
Impact of fetal umbilical cord blood CD34+ cells on breast cancer cell lines: a mechanism of fetal microchimerism?
Introduction Fetal microchimerism could be involved in the regulation of breast cancer oncogenesis. CD34+ cells could be of a particular interest as up to 12% of the CD34+ population in maternal blood are of fetal origin. The aim of this research was to analyze the impact of umbilical cord blood (UCB) CD34+ on MCF-7 and MDA-MB-231 breast cancer cell lines, in order to uncover novel biological mechanisms and suggest novel treatment options for breast cancer.
Les Territoires de Georges Saint-Clair (1921-2016)
Ayuda Buscar en la ayuda Buscar en la ayuda Les Territoires de Georges Saint-Clair (1921-2016) [1] Université de Pau et des pays de l’Adour Localización: Litteratures, ISSN 0563-9751, Nº. 89, 2024 (Ejemplar dedicado a: Géographie sensible), págs.
Knowledge and practices of youth awareness on death and dying in school settings: a systematic scoping review protocol - Systematic Reviews
Levac [19] scoping review method will be used. This method comprises six steps: (1) identify the review questions, (2) identify the literature, (3) select the literature, (4) extract data, (5) report the result, and (6) consult stakeholders. This protocol is registered with Open Science Framework (OSF) [20] and based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA- ScR) (see supplementary file 1).
AlgaeTraits.org: a trait database for seaweed species
The analysis of functional traits is important in evolutionary and ecological research, as well as biodiversity conservation.However, trait data are often scattered and terminology is often not standardized across taxonomic groups or biogeographical regions. As part of the development of a global trait database of marine species, we collated trait information for European seaweeds and structured the data within the standardised framework of the World Register of Marine Species (WoRMS).
Un prince peut en cacher un autre: Un mystérieux voyage de Gaston d'Orléans en Italie en avril 1629?
IdiomacatalàDeutschEnglishespañoleuskarafrançaisgalegoitalianoportuguêsromână
Clinical and histological features of histiocytoid Sweet syndrome associated with VEXAS syndrome
“Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic” (VEXAS) syndrome is caused by acquired somatic mutations in the ubiquitin-activating enzyme 1 (UBA1) gene. Sweet-syndrome-like skin disorders (and especially histiocytoid Sweet syndrome (HSS)) may be associated with VEXAS syndrome. To characterize the clinical and histopathological features of HSS in patients with VEXAS syndrome.
Analysis and design of three-dimensional porous composites based on graphene oxide modified with amine groups for energy storage
[ES] Este estudio se centra en la evaluación de la capacitancia específica para diferentes materiales activos de electrodos, basados en esponjas de óxido de grafeno como matriz y polipirrol como recubrimiento. La porosidad ...[+] [ES] Este estudio se centra en la evaluación de la capacitancia específica para diferentes materiales activos de electrodos, basados en esponjas de óxido de grafeno como matriz y polipirrol como recubrimiento.
The length of the 3′ UTR of the tomato torrado virus (ToTV) RNA1 affects virus accumulation in Solanum lycopersicum during mechanical passages from plant to plant
Filename Description ppa13834-sup-0001-PP-23-224_Fig_S1.tifTIFF image, 1.8 MB Figure S1. The comparison of an average copy number of ToTVpJL-Kra 3′ UTR RNA1 variants (var3/var4/var5) and a mixture of var1–var5 in Solanum lycopersicum after the third mechanical passage. The total RNA used for reverse transcription-quantitative PCR analyses was extracted from systemic leaves 10 days post-inoculation, from 15 tomato plants. An average copy number was estimated in the third passage, P3.
Approche du menteur: une analyse ontologique du paradoxe du crétois sur le mode de la généricité massive
Approche du menteur: une analyse ontologique du paradoxe du crétois sur le mode de la généricité massive Autores: Sylvain Le Gall Localización: Aporía: revista internacional de investigaciones filosóficas, ISSN 0718-9788, Nº. 25, 2023, págs.
Correction: Autophagy protein 5 controls flow-dependent endothelial functions
Cellular and Molecular Life Sciences, Sep 2023 This is a preview of a remote PDF: https://link.springer.com/content/pdf/10.1007/s00018-023-04916-3.pdf Nivoit, Pierre, Mathivet, Thomas, Wu, Junxi, Salemkour, Yann, Sankar, Devanarayanan Siva, Baudrie, Véronique, Bourreau, Jennifer, Guihot, Anne-Laure, Vessieres, Emilie, Lemitre, Mathilde, Bocca, Cinzia, Teillon, Jérémie, Le Gall, Morgane, Chipont, Anna, Robidel, Estelle, Dhaun, Neeraj, Camerer, Eric, Reynier, Pascal, Roux, Etienne, Couffinhal,...
The European Physical Journal Plus
The European Physical Journal Plus, Jul 2023 The continuous evolution of photon sources and their instrumentation enables more and new scientific endeavors at ever increasing pace.
Autophagy protein 5 controls flow-dependent endothelial functions
Cellular and Molecular Life Sciences, Jul 2023 Dysregulated autophagy is associated with cardiovascular and metabolic diseases, where impaired flow-mediated endothelial cell responses promote cardiovascular risk. The mechanism by which the autophagy machinery regulates endothelial functions is complex. We applied multi-omics approaches and in vitro and in vivo functional assays to decipher the diverse roles of autophagy in endothelial cells.
Using a multi-omic approach to investigate the mechanism of 12-bis-THA activity against Burkholderia thailandensis
1. Introduction Burkholderia pseudomallei is the causative agent of melioidosis, a disease of the tropics and sub-tropics which causes approximately 165,000 cases and 89,000 deaths annually (Limmathurotsakul et al., 2016). Bacterial transmission can occur through ingestion and inhalation however sub-cutaneous inoculation through contact with contaminated water and soil is thought to be the most common route of infection (Limmathurotsakul and Peacock, 2011).
The Ongoing Contribution of Health Impact Assessment to Health Promotion Research
Abstract There are many areas of convergence and mutual growth between health impact assessment (HIA) and health promotion. However, HIA is often considered a practical implementation tool and therefore not particularly suited for research. In fact, HIA is more than a tool, it is a health promotion approach and a means to effectively implement Health in All Policies (HiAP).
Ruthenium-Based Photoactivated Chemotherapy
Our eyes are not the only light-sensitive organs in humans. Our moods, our sleep, and our skin are also sensitive to sunlight. Artificial light sources entered clinical practice a long time ago, for example, to treat smallpox. (1) Newborn jaundice treatment is one of the best-known clinical application of phototherapy, (2) while skin tumors were treated with phototherapy in ancient Egypt.
Ruthenium-Based Photoactivated Chemotherapy
Our eyes are not the only light-sensitive organs in humans. Our moods, our sleep, and our skin are also sensitive to sunlight. Artificial light sources entered clinical practice a long time ago, for example, to treat smallpox. (1) Newborn jaundice treatment is one of the best-known clinical application of phototherapy, (2) while skin tumors were treated with phototherapy in ancient Egypt.
Frontiers | Comprehensive assessment of executive functioning following childhood severe traumatic brain injury: clinical utility of the child executive functions battery
Keywords: Performance-based tests, Brain Injuries, Child, executive functions, Everyday Life © 2023 Chevignard, Guerra, Fliss, Salah, Pineau, Notteghem, Roche, Huon, Krasny Pacini, Le Gall, Fournet, Roulin and Roy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Molecules | Free Full-Text | Catalyst-Free Formal Conjugate Addition/Aldol or Mannich Multicomponent Reactions of Mixed Aliphatic Organozinc Reagents, π-Electrophiles and Michael Acceptors
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessCommunication by Marine Pinaud , Marc Presset * and Erwan Le Gall * Univ Paris Est Créteil, CNRS, ICMPE, UMR 7182, 2 rue Henri Dunant, 94320 Thiais, France * Authors to whom correspondence should be addressed.
Corrigendum: "A Global Review on Locusts (Orthoptera: Acrididae) and Their Interactions With Livestock Grazing Practices"
Marion Le Gall1*, Rick Overson1 and Arianne Cease1 1Arizona State University, United States The final, formatted version of the article will be published soon. Receive an email when it is updated You just subscribed to receive the final version of the article Connections between locusts and people date back millennia and remain a major food security Q11 Q5 challenge throughout the world today.
Construct Validity of a Theory of Mind Assessment Battery Adapted to Tunisian School-Aged Children
Imen SALHI1*, Céline LANCELOT2, Yousri Marzouki3, Wided SOUISSI1, Aya N.
Concise review of the red macroalga dulse, Palmaria palmata (L.) Weber & Mohr
Journal of Applied Phycology, Jan 2023 This is a preview of a remote PDF: https://link.springer.com/content/pdf/10.1007/s10811-022-02899-5.pdf Stévant, Pierrick, Schmedes, Peter Søndergaard, Le Gall, Line, Wegeberg, Susse, Dumay, Justine, Rebours, Céline. , Journal of Applied Phycology, 2023, pp. 1-28, DOI: 10.1007/s10811-022-02899-5
Frontiers | Nutrient supply and accessibility in plants: effect of protein and carbohydrates on Australian plague locust (Chortoicetes terminifera) preference and performance
Jonah K. Brosemann1*, Rick Overson1, Arianne J. Cease1, Sydney C. Millerwise1 and Marion Le Gall1 1Arizona State University, United States The final, formatted version of the article will be published soon.
Fecal microbiota transplantation in a rodent model of short bowel syndrome: a therapeutic approach?
salma fourati1, 2, anne dumay2, 3, maryline roy2, alexandra willemetz2, lara Ribeiro-Parenti2, 3, 4, Camille Mayeur5, Aurélie Mauras5, muriel thomas5, Nathalie Kapel1, 3, francisca joly2, 3, 6, Maude LE GALL2, andre bado2 and Johanne Le Beyec1, 2, 7* 1Hôpitaux Universitaires Pitié Salpêtrière, France 2INSERM U1149 Centre de Recherche sur l'Inflammation, France 3Université de Paris, France 4Service de Chirurgie Générale, Digestive, Bariatrique et Oesogastrique, Hôpital Bichat-Claude-Bernard,...
The ecotoxicological consequences of microplastics and co-contaminants in aquatic organisms: a mini-review
‘Microplastics’ (MPs) is used as a catch-all term to represent a complex variety of properties that arise during both the manufacturing process and following release into the environment [1]. Plastics are composed of different organic polymers to which an array of chemicals (termed here as ‘endogenous chemicals’, e.g. plasticizers, colorants, fillers and stabilizers) are added to enhance certain properties, such as rigidity, malleability, or thermal resistance and prolonging life [2].
Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice - Cellular and Molecular Life Sciences
Abstract The gut microbiota plays a central role in regulating host metabolism. While substantial progress has been made in discerning how the microbiota influences host functions post birth and beyond, little is known about how key members of the maternal gut microbiota can influence feto-placental growth. Notably, in pregnant women, Bifidobacterium represents a key beneficial microbiota genus, with levels observed to increase across pregnancy.
Rhodolith Physiology Across the Atlantic: Towards a Better Mechanistic Understanding of Intra- and Interspecific Differences
Impact Factor 4.912 | CiteScore 5.0 More on impact › TABLE OF CONTENTS Nadine Schubert1*, Viviana Peña2‡, Vinícius W. Salazar3†‡, Paulo A. Horta3‡, Pedro Neves1,4‡, Cláudia Ribeiro1,4,5‡, Francisco Otero-Ferrer6,7‡, Fernando Tuya6‡, Fernando Espino6‡, Kathryn Schoenrock8‡, Laurie C.
Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain - Microbiome
Altered intestinal microbiota composition in old age is associated with chronic low-grade inflammation and increasing susceptibility to age-associated chronic diseases. However, whether age-associated changes in the diversity, composition, or function of the gut microbiota are causal in disease etiology remains largely unknown. Here, we used FMT between young and aged mice, to bi-directionally modulate recipient microbiota structure and metabolic capability.
Clock qubit conducts nuclear ensemble - Nature Physics
A rare-earth ion in a long-lived clock state can control a nearby ensemble of nuclear spins. Interfacing this pristine photon emitter with a small quantum processor may be a route towards making identical solid-state nodes for quantum networks. The leading challenge in quantum computing is to scale the number and connectivity of qubits beyond millions — a number required for fault-tolerant quantum computing.
Witnessing quantum correlations in a nuclear ensemble via an electron spin qubit - Nature Physics
References 1. Abanin, D. A., Altman, E., Bloch, I. & Serbyn, M. Colloquium: many-body localization, thermalization and entanglement. Rev. Mod. Phys. 91, 021001 (2019). ADS MathSciNet Article Google Scholar 2. Kaufman, A. M. et al. Quantum thermalization through entanglement in an isolated many-body system. Science 353, 794–800 (2016). ADS Article Google Scholar 3. Shimazaki, Y. et al. Strongly correlated electrons and hybrid excitons in a moiré heterostructure. Nature 580, 472–477 (2020).
On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection
23 References 679 Citing Articles Related Articles Abstract Background Antiretroviral preexposure prophylaxis has been shown to reduce the risk of human immunodeficiency virus type 1 (HIV-1) infection in some studies, but conflicting results have been reported among studies, probably due to challenges of adherence to a daily regimen. Methods We conducted a double-blind, randomized trial of antiretroviral therapy for preexposure HIV-1 prophylaxis among men who have unprotected anal sex with men.
"Wellspring-Ryan Lay in Palestine" Article
By Ryan Lay Photos by Seidler and Le Gall From inside the hospital, we heard muffled, agonizing screams and one by one patients walked out with beads of sweat on their foreheads. After I finally made my way into the doctor’s office, a few brief words in Arabic were spoken with my friend Aram Sabbah and the doctor began wrenching my bone like Play-Doh until my broken finger was mostly set straight.
Pour une histoire de la France libre
Patrick Harismendy et Erwan Le Gall (éd.) … Soixante-dix ans après l’évènement fondateur du 18 juin 1940 et malgré plusieurs ouvrages marquants qui font suite à un cortège de mémoires d’acteurs de premier plan, la France Libre reste mal connue.
Movements and trends in intensive care pain treatment and sedation: What matters to the patient?
Abstract Background Oversedation, delirium and immobilisation in the intensive care unit are associated with increased length of stay in the unit. Routines of systematic pain and sedation assessment and the use of valid tools are highly stressed in international guidelines.
Drug-resistant infections : a threat to our economic future (Vol. 2) : final report (English)
Complete Report in English Official version of document (may contain signatures, etc) Official PDF , 172 pages 3.75 mb TXT * (All language versions and volumes across World Bank Repositories) Download Stats by Country/Region Download Stats by HQ/Country Office Download Stats by Month/Year *The text version is uncorrected OCR text and is included solely to benefit users with slow connectivity. **Download statistics measured since January 1st, 2014
Subtidal Microphytobenthos: A Secret Garden Stimulated by the Engineer Species Crepidula fornicata
Introduction Microphytobenthos (MPB) refers to a complex assemblage of benthic unicellular eukaryotic algae (mainly diatoms) and cyanobacteria living at the sediment-water interface (MacIntyre et al., 1996). MPB is a major component of benthic biofilms, embedded with heterotrophic prokaryotes in a exopolysaccharides matrix (Underwood and Paterson, 2003).
GMO90+ Project: Absence of Evidence for Biologically Meaningful Effects of Genetically Modified Maize-based Diets on Wistar Rats After 6-Months Feeding Comparative Trial | Toxicological Sciences | Oxford Academic
The detection of potential toxicological effects of single chemical compounds tested in vivo is generally based on a 90-day (T90) rodent trial to assess any potential unintended effects.
New treatment paradigms for ADPKD: moving towards precision medicine
Abstract The natural history of autosomal dominant polycystic kidney disease (ADPKD) is characterized by a variable rate of cyst development and increase in total kidney volume (TKV), variable kidney function decline and age of onset of end-stage renal disease (ESRD), and variable presentation of renal and extrarenal manifestations.
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